Norepinephrine weaning in septic shock patients by closed loop control based on fuzzy logic

Mehdi Merouani¹ , Bruno Guignard² , François Vincent³ , Stephen W Borron⁴ , Philippe Karoubi³ , Jean-Philippe Fosse³ , Yves Cohen³ , Christophe Clec'h³ , Eric Vicaut⁵ , Carole Marbeuf-Gueye⁶ , Frederic Lapostolle¹ and Frederic Adnet¹

¹Samu 93 – EA 3409, Université Paris 13, Hôpital Avicenne, Rue de Stalingrad, 93000 Bobigny, France

²Département d'Anesthésie et de Réanimation, Hôpital Ambroise Paré, Avenue Charles-de-Gaulle, 92100 Boulogne Billancourt, France

³Service de Réanimation, Hôpital Avicenne, Rue de Stalingrad, 93000 Bobigny, France

⁴Department of Surgery (Emergency Medicine), University of Texas Health Science Center at San Antonio, Medical Drive, San Antonio, TX 78229, USA

⁵Unité de Recherche Clinique, Hôpital Fernand Widal, Rue Ambroise Paré, 75475 Paris Cedex, France

⁶BioMoCeTi, UMR 7033, UFR SMBH, Université Paris 13, Rue Marcel Cachin, 93000 Bobigny, France