Table 1 |
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Effect of extended infusion of carbapenem antibiotics |
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Bactericidal cumulative reaction of response (%)a |
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|
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Antibiotic regimen |
30-minute infusion |
3-hour infusion |
Change (%) |
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|
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|
Imipenem 1 g q8h |
69.3 |
72.0 |
+2.7 |
|
Meropenem 1 g q8h |
77.1 |
83.8 |
+6.7 |
|
Meropenem 2 g q8h |
84.1 |
88.1 |
+4.0 |
|
|
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Shown is the effect of extended infusion of carbapenem antibiotics on the bactericidal cumulative fraction of response against multidrug-resistant Pseudomonas aeruginosa [17]. aBactericidal exposure defined as 40% time above minimum inhibitory concentration. q8h, every 8 hours. |
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Nicolau Critical Care 2008 12(Suppl 4):S2 doi:10.1186/cc6818 |
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