Table 3

Histopathological scoring of osmotic nephrosis-like lesions, proliferating nuclear antigen and activated macrophages

HES 200

HES 130

RL

OL (score)

2.1 ± 0.6

2.0 ± 0.5

1.1 ± 0.4^a

PCNA (pc/vf)

18.8 ± 7.1

7.2 ± 1.7^b

14.1 ± 4.1

Interstitial

18.0 ± 6.9

6.5 ± 1.6^c

13.5 ± 4.0

Glomerular

1.2 ± 0.7

1.0 ± 0.3

0.9 ± 0.2

ED-1 (pc/vf)

1.3 ± 1.0

0.2 ± 0.04^d

0.4 ± 0.3

Data are presented as mean ± standard deviation.

^a RL vs. 10% HES 200/0.5 and RL vs. 6% HES 130/0.42; P = 0.002

^b 6% HES 130/0.42 vs. 10% HES 200/0.5; P = 0.008

^c 6% HES 130/0.42 vs. 10% HES 200/0.5; P = 0.006

^d 6% HES 130/0.42 vs. 10% HES 200/0.5; P = 0.044

ED-1 = activated macrophages; HES = hydroxyethyl starch; OL = osmotic nephrosis-like lesions; PCNA = proliferating nuclear antigen; RL = Ringer's lactate.

Hüter et al. Critical Care 2009 13:R23   doi:10.1186/cc7726