Table 1

Clinical studies of Ang-1, Ang-2 and soluble Tie2 in critically ill patients

Study

Patients

Ang-1

Ang-2

Soluble Tie2

Clinical effects

Lee et al. [33]

ACS: 82 AMI, 44 unstable angina, 40 stable CAD 40 HCs

NS

Higher in AMI versus HCs, SA, unstable angina

Higher in AMI versus HCs, SA, unstable angina

ND

Kugathasan et al. [23]

PAH: 6 idiopathic, 7 with other disease 8 HCs

NS

NS

Tie2 mRNA higher in lung of PAH patients versus HCs

ND

Parikh et al. [28]

ICU patients: 17 severe sepsis, 5 mild sepsis 29 HCs

NS

Higher in severe sepsis versus HCs

ND

Ang-2 levels correlate with low PaO₂/FiO₂

Gallagher et al. [180]

Vascular leakage: 14 IL-2, 14 IL-2+bevacizumab

ND

Higher during therapy

ND

Ang-2 levels rise on days of IL-2 therapy; high levels on day 3 predict vascular leakage (stop therapy)

Gallagher et al. [29]

ARDS: 45 ICU, 18 ARDS

ND

Higher in ARDS versus ICU patients; in ARDS, higher in nonsurvivors

ND

High levels of Ang-2 on day patient meets ARDS criteria. Ang-2 levels in ARDS patients correlate with mortality

Giuliano et al. [35]

Septic shock children: 20 SIRS 20 sepsis, 61 septic shock 15 HCs

Ang-1 lower in septic shock versus sepsis and SIRS

Higher in septic shock versus HCs, SIRS and sepsis

ND

ND

Orfanos et al. [37]

ICU patients: 6 no SIRS, 8 SIRS, 16 sepsis, 18 severe sepsis, 13 septic shock

ND

Higher in severe sepsis versus no SIRS and sepsis

ND

Ang-2 levels related to severe sepsis and TNF-α levels

Scholz et al. [181]

180 liver cirrhosis patients 40 HCs

ND

Higher in cirrhosis versus HCs

ND

ND

Ganter et al. [34]

208 trauma patients in ER

Unchanged

Higher within 30 minutes after ER admission

ND

Ang-2 levels correlate with met ISS and mortality. Ang-2 higher in nonsurvivors

van der Heijden et al. [39]

24 sepsis, 88 nonseptic critically ill 15 HCs

Ang-1 lower in sepsis and critical illness versus HCs

Higher in critically ill patients; higher in septic than nonseptic patients

ND

Ang-2 levels associated with pulmonary permeability oedema and severity of ALI in septic and nonseptic critically ill patients

Lukasz et al. [36]

94 critically ill medical ICU patients 30 HCs

Ang-1 correlated negatively with SOFA Score

Ang-2 correlates positively with SOFA Score

ND

Ang-1 correlates negatively and Ang-2 positively with SOFA score

Siner et al. [38]

Critically ill patients: 20 nonseptic (ICU), 10 sepsis, 12 severe sepsis, 24 septic shock

ND

Ang-2 increases with severity of sepsis

ND

Increase in Ang-2 associated with severity of illness and hospital mortality

ACS, acute coronary syndrome; AMI, acute myocardial infarction; ARDS, acute respiratory distress syndrome; CAD, coronary artery disease; ER, emergency room; Fi oxygen; HC, healthy control; ICU, intensive care unit; IL, interleukin; ISS, International Severity Score; ND, not determined; NS, not significant; PAH, pulmonary arterial hypertension; Pa pulmonary artery oxygen tension; SA, stable angina; SOFA, Sequential Organ Failure Assessment score; TNF, tumour necrosis factor.

van Meurs et al. Critical Care 2009 13:207   doi:10.1186/cc7153