Table 1 |
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|
Genetic association studies of the CD14 C-159T polymorphism and infectious disease |
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|
Reference |
Patients/cells |
n |
Association |
|
|
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|
[41] |
1st time MI male patients; mean age 55.9 ± 6.3 years |
178 cases, 135 controls, 18 volunteers |
T ↑ cases (OR 1.78) |
|
T ↑ mCD14 |
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|
[108] |
Children |
481 |
TT ↑ sCD14 (P = 0.01) |
|
[109] |
Patients with severe sepsis |
204 cases, 247 controls |
No difference in allele f between cases and controls; no association with mortality |
|
[110] |
Monocytes/hepatocytes |
T ↓ binding of Sp1,2,3, TFs |
|
|
[111] |
Healthy blood donors |
95 unstimulated blood samples |
No difference in sCD14, mCD14, or TNF concentration by genotype |
|
[34] |
White septic shock patients |
95 cases, 122 controls |
TT ↑ in septic shock patients and associated with ↑ risk of mortality |
|
[35] |
Severely injured blunt trauma patients |
58 cases, 95 controls |
No difference between cases and controls |
|
[36] |
ICU patients with SIRS |
77 cases, 39 controls |
No association with incidence of infection or outcome |
|
[112] |
PBMCs from healthy persons stimulated with bacterial ligands |
22 |
TT ↑ TNF-α mRNA levels after Escherichia coli or LPS stimulation |
|
[113] |
Healthy subjects |
315 |
TT ↑ risk for Chlamydia pneumoniae infection |
|
[114] |
Very low birth weight infants |
356 |
No association with development of blood-culture proven sepsis |
|
[115] |
Tuberculosis patients |
267 cases, 112 controls |
No association with tuberculosis or sCD14 levels |
|
[116] |
PBMCs and plasma from healthy individuals |
165 |
TT ↑ mCD14 |
|
TT and CT ↑ sCD14 |
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|
TT ↑ TNF-α after Chlamydia stimulation |
|||
|
[117] |
CAD patients (78 Chlamydia positive) |
610 |
T allele associated with ↑ likelihood of chronic Chlamydia infection |
|
[118] |
Acute pancreatitis |
117 cases, 263 controls |
No association with sCD14 or mCD14 |
|
No association with disease severity |
|||
|
[119] |
Acute pancreatitis |
77 cases, 71 controls |
No association with severity of pancreatitis |
|
[48] |
ICU patients with SIRS |
252 patients |
TT ↑ Gram negative cultures |
|
[39] |
Critically ill Japanese patients |
197 cases, 214 controls |
No association with sepsis or sepsis mortality |
|
[120] |
Blood from healthy individuals |
160 |
No association with cytokine release after stimulation |
|
[38] |
ICU patients in Brazil |
85 |
TT ↑ survival |
|
[121] |
Term neonates cord blood cultures |
135 |
CD14 -159T ↑ sCD14 in response to LPS |
|
[122] |
Children with invasive pneumococcal disease, healthy controls |
85 and 409, respectively |
↑ prevalence of CC genotype in patients with S. pneumoniae |
|
|
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|
CAD, coronary artery disease; f, frequency; ICU, intensive care unit; LPS, lipopolysaccharide; mCD14, membrane bound CD14; MI, myocardial infarction; OR, odds ratio; PBMC, peripheral blood mononuclear cell; sCD14, soluble CD14; TF, tissue factor; TNF, tumor necrosis factor. |
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Sutherland and Walley Critical Care 2009 13:210 doi:10.1186/cc7702 |
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