Table 1

Glycemia and mortality in three randomized controlled trials to assess the benefit of intensive insulin therapy

Glycemic control, mmol/L^a

Insulin protocol application

Mortality

Conventional

IIT

Conventional

IIT

Conventional

IIT

P value

Leuven I trial [7]

8.5 ± 1.8

5.7 ± 1.1

307/783

(39.2%)

755/765

(98.7%)

63/783

(8.0%)

35/765

(4.6%)

<0.04

Leuven II trial [8]

8.5 ± 1.7

6.2 ± 1.6

426/605 <0.04

580/595

(98%)

162/605

(26.8%)

144/595

(24.2%)

0.31

VISEP study [13]

8.4 ± 1.8

6.2 ± 1.0

215/290

(74.1%)

243/247

(98.4%)

75/289

(26.0%)

61/247

(24.7%)

0.74

^aGlycemic control values are presented as mean ± standard deviation. IIT, intensive insulin therapy; VISEP, Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis.

Egi et al. Critical Care 2009 13:302   doi:10.1186/cc7755