Table 2

Oxygen delivery, extraction, and other variables

sDO₂I^{a, b} (mL/kg per minute)

sER^a-c (percentage)

mDO₂I^b (mm Hg/kg per minute)

Mesent lac (mmol/L)

Arterial Hb^b (g/L)

Arterial pH

Arterial pO₂ (mm Hg)

Arterial pCO₂ (mm Hg)

Arterial BE (mmol/L)

Restricted Ringer lactate solution (R-RL)

0 minutes

109 ± 11

49 ± 5

25 ± 2

1.5 ± 0.4

101 ± 7

7.51 ± 0.02

138 ± 9

36 ± 2

5.4 ± 0.9

60 minutes

103 ± 11

48 ± 6

26 ± 2

1.4 ± 0.6

102 ± 6

7.51 ± 0.02

135 ± 10

36 ± 3

5.3 ± 1.2

180 minutes

97 ± 12

50 ± 6

21 ± 2

1.2 ± 0.3

105 ± 9

7.5 ± 0.02

134 ± 15

36 ± 2

4.5 ± 1.7

240 minutes

97 ± 12

50 ± 4

20 ± 1

1.3 ± 0.2

104 ± 6

7.49 ± 0.04

135 ± 12

37 ± 2

4.3 ± 2.0

Goal-directed Ringer lactate solution (GD-RL)

0 minutes

109 ± 17

51 ± 4

26 ± 6

1.4 ± 0.2

100 ± 10

7.52 ± 0.05

132 ± 11

37 ± 3

6.3 ± 1.9

60 minutes

116 ± 19

50 ± 4

30 ± 8

1.2 ± 0.2

99 ± 10

7.52 ± 0.04

132 ± 10

36 ± 2

6.4 ± 2.0

180 minutes

134 ± 26

44 ± 4

27 ± 6

1.2 ± 0.3

96 ± 6

7.49 ± 0.037

127 ± 10

38 ± 2

5.6 ± 2.0

240 minutes

130 ± 18

42 ± 7

26 ± 7

1.2 ± 0.3

90 ± 8

49 ± 0.03

126 ± 9

38 ± 3

5.1 ± 2.1

Goal-directed colloid solution (GD-C)

0 minutes

116 ± 18

50 ± 6

26 ± 6

1.4 ± 0.4

97 ± 12

7.52 ± 0.03

135 ± 12

37 ± 3

5.8 ± 1.2

60 minutes

141 ± 22^c

38 ± 5^{b, c}

35 ± 8

0.9 ± 0.2

86 ± 10

7.5 ± 0.02

132 ± 17

38 ± 3

5.7 ± 1.4

180 minutes

151 ± 33^d

38 ± 4^{d, e}

29 ± 6^d

0.8 ± 0.3

89 ± 11^d

7.49 ± 0.02

131 ± 14

38 ± 1

5.0 ± 1.3

240 minutes

158 ± 38^d

37 ± 5^d

27 ± 5^d

0.8 ± 0.3

87 ± 12^d

7.49 ± 0.02

128 ± 16

37 ± 1

4.6 ± 1.0

Data are presented as mean ± standard deviation. t = 0 baseline values are from before the start of the respective fluid therapy. The measurements were performed hourly for 4 hours. Significant differences (P < 0.05) for area under the curve: ^aR-RL versus GD-RL, ^bR-RL versus GD-C, ^cGD-RL versus GD-C. Significant differences (P < 0.05) for analysis of variance for repeated measurements (Tukey post hoc test): ^dR-RL versus GD-C, ^eGD-RL versus GD-C. The R-RL group received 3 mL/kg per hour of lactated Ringer solution throughout the entire experiment. The GD-RL group received 3 mL/kg per hour of lactated Ringer solution plus 250 mL of lactated Ringer solution if SvO₂ was less than 60%. The GD-C group received 3 mL/kg per hour of lactated Ringer solution plus 250 mL of hydroxyethyl starch (130/0.4) if SvO₂ was less than 60%. BE, standard base excess; Hb, hemoglobin concentration; mDO₂I, mesenteric oxygen delivery; mesent lac, mesenteric venous lactate; pCO₂, carbon dioxide partial pressure; pO₂, oxygen partial pressure; sDO₂, systemic oxygen delivery index; sER, systemic oxygen extraction ratio.

Hiltebrand et al. Critical Care 2009 13:R40   doi:10.1186/cc7761