Critical Care

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Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury

Sergio Vesconi1, Dinna N Cruz2*, Roberto Fumagalli3, Detlef Kindgen-Milles4, Gianpaola Monti1, Anibal Marinho5, Filippo Mariano6, Marco Formica7, Mariano Marchesi8, René Robert9, Sergio Livigni10, Claudio Ronco2 and the DOse REsponse Multicentre International collaborative Initiative (DO-RE-MI Study Group)

Author Affiliations

1 Department of Anesthesiology and Intensive Care, Hospital Niguarda, Piazza dell'Ospedale Maggiore 3, 20162, Milan, Italy

2 Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy

3 Department of Anaesthesiology and Intensive Care I, St Gerardo dei Tintori Hospital, Via giovanni Pergolesi 33, 20100 Monza, Italy

4 Anesthesiology Clinic, University of Düsseldorf, Moorenstrasse 5, 40225 Germany

5 Hospital Center of Porto, Alameda do Prof. Hernâni Monteiro, 4200 Paranhos, Porto, Portugal

6 Nephrology and Dialysis Unit, CTO Hospital, Via Gianfranco Zuretti 29, 10126 Turin, Italy

7 Department of Nephrology, Hospital Santa Croce e Carle, Via Michele Coppino 26, 12100 Cuneo, Italy

8 Department of Anaesthesiology and Intensive Care, Riuniti di Bergamo Hospital, Via Tito Livio 2, 24123 Bergamo, Italy

9 Intensive Care Unit, University of Poitiers, 2, rue de la Miletrie, 86021, Poitiers, France

10 Department of Intensive Care, Giovanni Bosco Hospital, Piazza Del Donatore di Sangue 3, 10154 Torino, Italy

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Critical Care 2009, 13:R57 doi:10.1186/cc7784


See related commentary by Lameire et al., http://ccforum.com/content/13/3/155

Published: 15 April 2009

Additional files

Additional data file 1:

A Word file containing a more detailed description of the study methodology.

Format: DOC Size: 41KB Download file

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Additional data file 2:

A Word file containing three tables and three figures as listed. Table 1: Characteristics of participating centres. Table 2: Clinical characteristics of continuous renal replacement therapy (CRRT) patients by tertiles of RRT dose. Table 3: Unadjusted, covariate adjusted, and covariate + propensity score-adjusted analysis for intensive care unit (ICU) mortality in CRRT patients. Figure 1: Distribution of RRT dose by RRT modality. (a) CRRT, (b) intermittent RRT; Figure 2: Kaplan Meier curve for ICU survival by tertiles of CRRT dose; Figure 3: Kaplan Meier curve for ICU survival by CRRT dose (≤ 20, 21 to 34, and ≥ 35 ml/kg/hour).

Format: DOC Size: 109KB Download file

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