Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury

doi:10.1186/cc7784

Critical Care
Volume 13
Issue 2

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Vesconi S
Cruz DN
Fumagalli R
Kindgen-Milles D
Monti G
Marinho A
Mariano F
Formica M
Marchesi M
Robert R
Livigni S
Ronco C

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Vesconi S
Cruz DN
Fumagalli R
Kindgen-Milles D
Monti G
Marinho A
Mariano F
Formica M
Marchesi M
Robert R
Livigni S
Ronco C
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Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury

Sergio Vesconi^*¹ , Dinna N Cruz^*² , Roberto Fumagalli³ , Detlef Kindgen-Milles⁴ , Gianpaola Monti¹ , Anibal Marinho⁵ , Filippo Mariano⁶ , Marco Formica⁷ , Mariano Marchesi⁸ , René Robert⁹ , Sergio Livigni¹⁰ and Claudio Ronco² for the DOse REsponse Multicentre International collaborative Initiative (DO-RE-MI Study Group)

¹Department of Anesthesiology and Intensive Care, Hospital Niguarda, Piazza dell'Ospedale Maggiore 3, 20162, Milan, Italy

²Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy

³Department of Anaesthesiology and Intensive Care I, St Gerardo dei Tintori Hospital, Via giovanni Pergolesi 33, 20100 Monza, Italy

⁴Anesthesiology Clinic, University of Düsseldorf, Moorenstrasse 5, 40225 Germany

⁵Hospital Center of Porto, Alameda do Prof. Hernâni Monteiro, 4200 Paranhos, Porto, Portugal

⁶Nephrology and Dialysis Unit, CTO Hospital, Via Gianfranco Zuretti 29, 10126 Turin, Italy

⁷Department of Nephrology, Hospital Santa Croce e Carle, Via Michele Coppino 26, 12100 Cuneo, Italy

⁸Department of Anaesthesiology and Intensive Care, Riuniti di Bergamo Hospital, Via Tito Livio 2, 24123 Bergamo, Italy

⁹Intensive Care Unit, University of Poitiers, 2, rue de la Miletrie, 86021, Poitiers, France

¹⁰Department of Intensive Care, Giovanni Bosco Hospital, Piazza Del Donatore di Sangue 3, 10154 Torino, Italy

author email corresponding author email* Contributed equally

Critical Care 2009, 13:R57doi:10.1186/cc7784


Published:	15 April 2009

See related commentary by Lameire et al., http://ccforum.com/content/13/3/155

Additional files

Additional data file 1:

A Word file containing a more detailed description of the study methodology.

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Additional data file 2:

A Word file containing three tables and three figures as listed. Table 1: Characteristics of participating centres. Table 2: Clinical characteristics of continuous renal replacement therapy (CRRT) patients by tertiles of RRT dose. Table 3: Unadjusted, covariate adjusted, and covariate + propensity score-adjusted analysis for intensive care unit (ICU) mortality in CRRT patients. Figure 1: Distribution of RRT dose by RRT modality. (a) CRRT, (b) intermittent RRT; Figure 2: Kaplan Meier curve for ICU survival by tertiles of CRRT dose; Figure 3: Kaplan Meier curve for ICU survival by CRRT dose (≤ 20, 21 to 34, and ≥ 35 ml/kg/hour).

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