Table 2

Time course after LPS challenge in healthy subjects

Time course after LPS challenge

Variables

Pre-dose

1 hour

1.5 hours

2 hours

2.5 hours

3.5 hours

4.5 hours

6.5 hours

8 hours

24 hours

P value

Systolic BP (mmHg)

140 ± 14

139 ± 11

152 ± 11

158 ± 18

151 ± 18

142 ± 22

121 ± 18

107 ± 11

104 ± 11

131 ± 11

< 0.0001

Diastolic BP (mmHg)

74 ± 10

74 ± 7

80 ± 7

77 ± 12

65 ± 12

61 ± 14

54 ± 11

55 ± 8

55 ± 7

66 ± 7

< 0.0001

MAP (mmHg)

96 ± 11

96 ± 9

104 ± 7

104 ± 13

94 ± 14

88 ± 16

77 ± 13

72 ± 8

71 ± 7

88 ± 7

< 0.0001

Heart rate (beats/minute)

61 ± 16

59 ± 11

78 ± 19

78 ± 18

92 ± 12

98 ± 8

101 ± 8

97 ± 11

96 ± 13

81 ± 16

< 0.0001

HR/MAP index

0.64 ± 0.11

0.62 ± 0.11

0.75 ± 0.17

0.76 ± 0.22

1.01 ± 0.22

1.15 ± 0.26

1.36 ± 0.32

1.36 ± 0.27

1.4 ± 0.22

0.92 ± 0.16

< 0.0001

Body temperature (°C)

35.4 ± 0.38

36.2 ± 0.54

36.4 ± 0.87

37.0 ± 1.04

37.6 ± 1.11

38.5 ± 0.66

38.9 ± 0.53

38.14 ± 0.28

37.9 ± 0.19

36.2 ± 0.29

< 0.0001

White blood count (10³/μl)

5.5 ± 0.7

-

-

-

-

-

-

-

-

10.9 ± 1.6

0.03

C-reactive protein (mg/l)

1.1 ± 2.4

0.9 ± 1.8

-

-

1.5 ± 2.4

2.2 ± 2.5

1.1 ± 2.3

1.8 ± 2.8

4.8 ± 2.0

60.0 ± 21.5

< 0.0001

Ang-1 (ng/ml)

67.0 ± 20.7

58.2 ± 24.4

-

-

61.2 ± 25.0

54.3 ± 19.5

-

64.9 ± 29.1

60.3 ± 31.4

52.3 ± 21.6

0.053

Ang-2 (ng/ml)

0.57 ± 0.50

0.63 ± 0.20

1.04 ± 0.65

1.63 ± 0.89

2.33 ± 0.69

2.35 ± 1.06

2.42 ± 1.32

2.23 ± 1.18

1.61 ± 1.07

1.51 ± 1.03

< 0.0001

Tie2 (ng/ml)

1.34 ± 0.31

1.23 ± 0.29

1.33 ± 0.32

1.53 ± 0.52

1.23 ± 0.20

1.3 ± 0.16

1.31 ± 0.35

1.4 ± 0.3

1.25 ± 0.32

1.43 ± 0.42

0.085

A non-parametric repeated-measures analysis of variance (Friedman's test) was used to test for significant changes of variables during the time course after LPS challenge (placebo group; n = 6). ANG = angiopoietin; BP = blood pressure; HR = heart rate; LPS = lipopolysaccharide; MAP = mean arterial pressure.

Kümpers et al. Critical Care 2009 13:R64   doi:10.1186/cc7866