Table 2

Characteristics of studies assessing the rate of cytomegalovirus pneumonia in critically ill patients

CMV infection

Outcome CMV positive vs. negative

Study

Inclusion criteria

Number of patients

CMV IgG^a

Time of histologic examination, day

Methods

Rate^a

Mortality, death/total (%)

ICU stay

[31]

ICU, acute respiratory failure or VAP, negative BAL cultures

86

13/18 (72)

18 (10–40)^b

Autopsy or open-lung biopsy

25/86 (29)

ND

No difference

[30]

ICU, ≥ 5 days of evolution of ARDS, negative microbiological cultures

36

ND

10 (5–55)^c

Open-lung biopsy

18/36 (50)

ND

ND

[29]

ICU, ≥ 5 days of evolution of ARDS, negative microbiological cultures

100^d

ND

7 (6–13.5)^c

Open-lung biopsy

30/100 (30)

ND

ND

Lung tissue culture

10/100 (10)

ARDS = acute respiratory distress syndrome; BAL = bronchoalveolar lavage; CMV = cytomegalovirus; ICU = intensive care unit; NA = not applicable; ND = no data available; VAP = ventilator-associated pneumonia.

^a Data were presented as positive/total (%).

^b Time was measured after the ICU admission.

^c Time was measured after the onset of ARDS.

^d Four immunocompromised patients were included.

Osawa and Singh Critical Care 2009 13:R68   doi:10.1186/cc7875