Table 3 |
||||
|
Epithelial cell apoptosis |
||||
|
Groups |
Lung |
Kidney |
Liver |
Villi |
|
|
||||
|
C-SAL |
0.0 (0 to 1) |
0.0 (0 to 1) |
0.0 (0 to 1) |
0.0 (0 to 1) |
|
C-Gln |
0.0 (0 to 1) |
0.5 (0 to 1) |
0.5 (0 to 1) |
0.0 (0 to 1) |
|
CLP-SAL |
2.5 (2 to 4)* |
2.0 (2 to 3)* |
2.0 (2 to 3)* |
3.5 (3 to 4)* |
|
CLP-Gln |
1.5 (1 to 2)* # |
1.0 (1 to 1)* # |
0.5 (0 to 1) |
0.0 (0 to 1) |
|
|
||||
|
Values are median (25th to 75th percentile) of five animals in each group. A five-point semiquantitative severity-based scoring system was used. The apoptotic findings were graded as: 0 = normal lung parenchyma; 1 = 1 to 25%; 2 = 26 to 50%; 3 = 51 to 75%; 4 = 76 to 100% of examined tissue. Sepsis was induced by cecal ligation and puncture surgery (CLP). A sham-operated group was used as control group (C) for animals undergoing CLP. One hour after surgery, C and CLP groups were further randomized into subgroups receiving saline (SAL) or glutamine (Gln). *Significantly different from C group (P < 0.05). #Significantly different from CLP-SAL group (P < 0.05). |
||||
|
Oliveira et al. Critical Care 2009 13:R74 doi:10.1186/cc7888 |
||||
