Figure 3.

Comparison of cytokeratin measurements in patients with impaired and preserved liver function in the septic group at baseline and at 48 and 120 hours. Concentrations were measured of total cytokeratin-18 (CK-18) and CK-18 fragments (CK-18-F), and the ratio of CK-18-F to total CK-18 was calculated from the sera of patients with sepsis and impaired liver function ('Liver-Sequential Organ Failure Assessment (SOFA) ≥1', bilirubin ≥1.2 mg/dL or 20.5 μmol/L according to SOFA score, dark grey box) compared with patients with sepsis and preserved liver function ('Liver-SOFA = 0', bilirubin <1.2 mg/dL or 20.5 μmol/L according to SOFA score, white box) at the time of diagnosis of sepsis (t0), and 48 hours (t48) and 120 hours (t120) later. Data in box plots are given as median, 25^th percentile, 75^th percentile, and the 1.5 interquartile range. Outliers are shown in form of circles (1.5 to 3 interquartile ranges above 75^th percentile or below 25^th percentile) or rectangles (>3 interquartile ranges above 75^th percentile or below 25^th percentile). * P < 0.05: ** P < 0.01.