Table 3

Comparison of inflammatory marker levels and cytokeratin measurements in survivors and non-survivors in the septic group at baseline and at 48 and 120 hours

Survivor (n = 52)

Non-survivor (n = 49)

P value

IL-6 (pg/ml)

t0

104.5; 34.0 to 430.0

249.4; 96.5 to 460.2

0.099

t48

21.0; 8.0 to 46.0

82.1; 37.4 to 188.5

0.001**

t120

17.2; 8.9 to 38.3

71.6; 15.7 to 107.1

0.01*

P value

t0-t48-t120

< 0.001***

0.005**

sICAM-1 (ng/ml)

t0

447.5; 323.14 to 663.6

399.8; 327.9 to 655.4

0.841

t48

434.1; 308.6 to 613.6

683.2; 348.3 to 1003.7

0.067

t120

467.8; 320.4 to 593.0

630.2; 419.2 to 933.3

0.083

P value

t0-t48-t120

0.432

0.829

sVCAM-1 (ng/ml)

t0

1146.3; 911.3 to 1975.7

1227.5; 857.2 to 2242.5

0.837

t48

882.0; 569.6 to 1236.1

1275.1; 1040.0 to 2799.2

0.027*

t120

748.5; 639.1 to 1202.6

1685.5; 958.7 to 2201.2

0.021*

P value

t0-t48-t120

0.097

0.505

Total CK-18 (U/l)

t0

1581.9; 1030.0 to 2152.0

2006.5; 1169.9 to 4611.6

0.038*

t48

1579.5; 1359.8 to 2058.7

2007.1; 1239.0 to 4488.8

0.212

t120

1829.6; 1581.9 to 2076.9

2533.0; 1675.2 to 3535.5

0.073

P value

t0-t48-t120

0.396

0.814

CK-18 fragments (U/l)

t0

357.7; 248.8 to 554.8

475.4; 301.5 to 1028.2

0.035*

t48

355.4; 229.0 to 455.46

603.6; 410.7 to 973.5

0.007**

t120

324.6; 283.7 to 499.9

508.5; 314.8 to 881.3

0.108

P value

t0-t48-t120

0.717

0.939

Ratio

t0

0.3; 0.16 to 0.33

0.2; 0.12 to 0.36

0.436

t48

0.2; 0.15 to 0.30

0.3; 0.15 to 0.35

0.651

t120

0.2; 0.15 to 0.27

0.3; 0.15 to 0.36

0.534

P value

t0-t48-t120

0.405

0.939

Data are presented by median and interquartile range (Q1 to Q3).

CK = cytokeratin; sICAM = soluble intercellular adhesion molecule-1; sVCAM = soluble vascular cell adhesion molecule-1.

* P < 0.05; ** P < 0.01; *** P < 0.001.

Hofer et al. Critical Care 2009 13:R93   doi:10.1186/cc7923