Commentary Macrophage migration inhibitory factor, infection, the brain, and corticosteroidsDepartment of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, PO Box 22660, 1100DD Amsterdam, The Netherlands
Critical Care 2009, 13:170doi:10.1186/cc7970
See related research by Østergaard and Benfield, http://ccforum/content/13/3/R101 AbstractBacterial meningitis is a complex disorder in which injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a neuro-endocrine mediator that might play a role in pneumococcal meningitis. Here, we discuss the role of MIF in infection, the brain, and corticosteroids and conclude that experimental meningitis studies have to determine whether MIF is a potential target for adjunctive therapy in pneumococcal meningitis. |




on Google Scholar








author email
corresponding author email