Table 3 |
|||||
|
Performance of serum IL-6 and IL-8 for the diagnosis of acute kidney injury at various times after cardiopulmonary bypass |
|||||
|
Sensitivity (%) |
Specificity (%) |
Positive predictive value (%)* |
Negative predictive value (%)* |
Area under the ROC curve |
|
|
|
|||||
|
IL-6 at 2 hours |
0.76 |
||||
|
≥175 pg/ml |
44 |
85 |
63 |
73 |
|
|
≥125 pg/ml |
78 |
80 |
69 |
87 |
|
|
≥75 pg/ml |
83 |
25 |
39 |
73 |
|
|
IL-6 at 12 hours |
0.71 |
||||
|
≥175 pg/ml |
17 |
100 |
100 |
68 |
|
|
≥125 pg/ml |
22 |
100 |
100 |
70 |
|
|
≥75 pg/ml |
50 |
89 |
72 |
76 |
|
|
|
|||||
|
IL-8 at 2 hours |
0.74 |
||||
|
≥100 pg/ml |
44 |
80 |
56 |
72 |
|
|
≥70 pg/ml |
67 |
65 |
52 |
78 |
|
|
≥40 pg/ml |
83 |
45 |
46 |
83 |
|
|
IL-8 at 12 hours |
0.82 |
||||
|
≥100 pg/ml |
18 |
100 |
100 |
68 |
|
|
≥70 pg/ml |
35 |
100 |
100 |
73 |
|
|
≥40 pg/ml |
71 |
74 |
60 |
82 |
|
|
|
|||||
|
*Because positive and negative predictive values will vary based on AKI prevalence, we assumed a prevalence of 36%, as in [17]. |
|||||
|
Liu et al. Critical Care 2009 13:R104 doi:10.1186/cc7940 |
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