Table 3 |
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|
Population pharmacokinetic parameters of epinephrine in 38 patients with septic shock and bootstrap statistics |
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|
Parameter |
Mean |
SE (%) |
Mediana |
5th to 95th percentilesa |
|
|
||||
|
CL (L/hr/70 kg BW/50 SAPS II units) |
127 |
6.0 |
125 |
115 to 140 |
|
V (L) |
7.9 |
36 |
7.4 |
1 to 13 |
|
R0 (nmol/h) |
43.5 |
24 |
43 |
1 to 65 |
|
θBW effect on CL |
0.60 |
33 |
0.59 |
0.23 to 0.95 |
|
θSAPS II effect on CL |
-0.67 |
21 |
-0.65 |
-0.91 to -0.43 |
|
BSV(CL) (square root of ω2CL) |
0.33 |
31 |
0.30 |
0.20 to 0.39 |
|
BSV(R0) (square root of ω2R0) |
1.23 |
20 |
1.23 |
1 to 2.85 |
|
Residual variability, proportional component |
0.1b |
NA |
NA |
NA |
|
Residual variability, additive component, nmol/L |
0.1b |
NA |
NA |
NA |
|
|
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|
aStatistics from 387 bootstrap runs (13 abnormal termination runs). Non parametric 90% confidence interval based on the 5th to 95th percentiles. bFixed values. BSV = between subject variability; BW = body weight; CL = epinephrine clearance; NA = not applicable; R0 = baseline rate of epinephrine infusion; SAPS II = new simplified acute physiology score; SE (%) = standard error of estimate in %; V = epinephrine distribution volume. θBW effect on CL, CL = 127 (BW/70)0.60, the individual CL increases or decreases as a function of BW, it is > 127 L/hr if BW is > 70 kg and < 127 L/hr if BW < 70 kg. θSAPSII effect on CL, CL = 127 (SAPSII/50)-0.67, the individual CL increases or decreases as a function of SAPS II score, it is > 127 L/hr if SAPS II is < 50 and < 127 L/hr if SAPS II > 50 units. |
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|
Abboud et al. Critical Care 2009 13:R120 doi:10.1186/cc7972 |
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