Table 2

Randomized controlled trials of ventilator weaning strategies

Impact on

Subjects

VAP rates

Ventilator LOS

ICU LOS

Hospital LOS

Mortality

Daily spontaneous breathing trial

Esteban, et al., 1995 [35]

546

-

40% ↓

(-2 days)

-

-

-

Ely, et al., 1996 [34]

300

-

25% ↓

(-1.5 days)

NS

NS

NS

Kollef, et al., 1997 [33]

357

-

20% ↓

(-0.4 days)

-

NS

NS

Marelich, et al., 2000 [32]

385

NS

45% ↓

(-2.3 days)

-

-

NS

Lellouche, et al., 2006 [36]

144

NS

38% ↓

(-4.5 days)

22.6% ↓

(-3.5 days)

NS

NS

Daily sedative interruption

Kress, et al., 2000 [37] and

128

NS

33% ↓

(-2.4 days)

35% ↓

(-3.5 days)

NS

NS

Schweickert, et al., 2004 [65]

Daily spontaneous breathing trial and sedative interruption

Girard, et al., 2008 [38]

336

-

19% ↓

(-3.1 days)

29% ↓

(-3.8 days)

22% ↓

(-4.3 days)

28 days: NS

1 year: 32% ↓

ICU, intensive care unit; LOS, length of stay; NS, no statistically significant impact; VAP, ventilator-associated pneumonia; Ventilator LOS, duration of mechanical ventilation.

Klompas Critical Care 2009 13:315   doi:10.1186/cc8036