Table 1 |
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|
Total cell and neutrophil counts in bronchoalveolar lavage fluid |
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|
Total cells |
Neutrophils |
MPO |
|
|
|
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|
Controls |
21 (19-24) |
0 (0-0) |
32 (20-59) |
|
Streptococcus pneumoniae pneumonia (t = 40 hours) |
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|
Placebo |
171 (92-206) |
73 (39-112) |
99 (53-106) |
|
rh-aPC |
208 (122-233) |
86 (56-104) |
186 (66-265) |
|
AT |
36 (23-38)* |
1 (0-5)** |
68 (24-74) |
|
Heparin |
417 (313-579) |
92 (69-114) |
498 (224-932)* |
|
Danaparoid |
542 (462-681) |
111 (99-125) |
407 (167-535) |
|
|
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|
Cell counts 40 hours after bacterial challenge (Streptococcus pneumoniae, serotype 3, ATCC 6303). Controls are uninfected rats (n = 4). Total cell and neutrophil data are expressed as median (interquartile range) × 104 per milliliter of bronchoalveolar lavage fluid. Myeloperoxidase (MPO) is expressed as pg/mL lung homogenate median (interquartile range). (* P < 0.05;** P < 0.01 versus placebo according to Kruskal-Wallis and Dunn's post-tests). rh-aPC = recombinant human activated protein C; AT = antithrombin. |
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Hofstra et al. Critical Care 2009 13:R145 doi:10.1186/cc8040 |
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