Figure 1.

Algorithm for initiation of renal replacement therapy in critically ill patients. *'Optimized resuscitation' of the kidney should also include discontinuation/withholding nephrotoxic medications and anti-hypertensive medications that may exacerbate kidney function. ^§Exogenous toxins (see [56]) and selected endogenous toxins (for example, myoglobin; see text). AKI, acute kidney injury; AKIN, Acute Kidney Injury Network; RRT, renal replacement therapy.