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Letter

RIFLE is not RIFLE: on the comparability of results

Lars Englberger*, Rakesh M Suri and Hartzell V Schaff

Author Affiliations

Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55905, USA

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Critical Care 2009, 13:429 doi:10.1186/cc8175

Published: 9 December 2009

First paragraph (this article has no abstract)

In the consensus RIFLE criteria [1] of acute kidney injury (AKI) the thresholds given for serum creatinine (sCr) increase and glomerular filtration rate (GFR) decrease (Table 1) do not correspond [2]. Direct measurement of GFR in clinical practice is difficult, and values are more often estimated (eGFR) by the Cockroft-Gault equation or the Modification of Diet in Renal Disease (MDRD) formula. In addition, there is controversy in the literature whether eGFR provides more clinical information regarding AKI than changes in sCr [3].