Table 4 |
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|
Correlation of SNPs in the mbl2 gene with the serum MBL level |
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|
Normal control |
Severe sepsis |
Septic shock |
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|
|
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|
Loci |
Allele |
Genotype |
Median (IQR) μg/L |
Pa |
Median (IQR) μg/L |
Pa |
Median (IQR) μg/L |
Pa |
|
|
||||||||
|
-550 |
H |
GG |
2493 (1452--3992) |
0.000 |
2250 (1285--4800) |
0.000 |
2550 (2010--3945) |
0.000 |
|
GC |
955 (335--2626) |
810 (600--1360) |
1530bc (860--2400) |
|||||
|
L |
CC |
384 (0--1284) |
340 (275--710) |
640c (300--1630) |
||||
|
Gly54 Asp |
A |
GG |
2249 (1333--3352) |
0.000 |
1370 (825--3925) |
0.000 |
2280 (1500--2800) |
0.000 |
|
GA |
315 (3--540) |
460b (335--695) |
475b (298--695) |
|||||
|
B |
AA |
0 |
270 (135-280) |
270 |
||||
|
+4 |
P |
CC |
1039 (215--2668) |
0.036 |
800 (430--1363) |
0.367 |
1910bc (1045--2635) |
0.470 |
|
CT |
2182 (1187--2826) |
800 (370--4265) |
1605 (488--3013) |
|||||
|
Q |
TT |
4823 |
2895 (830--4960) |
3570 |
||||
|
|
||||||||
|
Data are expressed as the median and interquartile range (IQR; 25% to 75%). a = P-value based on the Kruskal--Wallis or Mann--Whitney U test. Statistical differences in the mannose-binding lectin (MBL) levels were analyzed according to genotype within each subgroup. b = P < 0.05 vs. the control group. c = P < 0.05 vs. the severe sepsis group. SNP = single nucleotide polymorphism. |
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|
Huh et al. Critical Care 2009 13:R176 doi:10.1186/cc8157 |
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