Table 3 |
|||||
|
Risk factors of bleeding complications in children with CRRT |
|||||
|
Bleeding |
No bleeding |
P |
|||
|
Mean |
SD |
Mean |
SD |
||
|
|
|||||
|
Age (months) |
64.2 |
70.8 |
49.5 |
62.3 |
0.385 |
|
|
|||||
|
Weight (kg) |
22.7 |
22.0 |
16.6 |
17.5 |
0.310 |
|
|
|||||
|
PRISM score |
15.0 |
7.0 |
14.7 |
8.5 |
0.643 |
|
|
|||||
|
PIM score |
-2.1 |
0.9 |
-2.0 |
1.5 |
0.929 |
|
|
|||||
|
PELOD score |
18.1 |
9.2 |
17.5 |
8.1 |
0.402 |
|
|
|||||
|
Number of failed organs |
3.3 |
1.1 |
2.9 |
1.1 |
0.189 |
|
|
|||||
|
Lactic acid (mmol/L) |
4.3 |
5.4 |
2.9 |
3.4 |
0.530 |
|
|
|||||
|
Arterial pH |
7.31 |
0.1 |
7.31 |
0.1 |
0.906 |
|
|
|||||
|
MAP (mmHg) |
56.2 |
22.7 |
62.0 |
18.2 |
0.211 |
|
|
|||||
|
Dose of adrenaline (μg/kg/min) |
0.5 |
0.6 |
0.5 |
1.2 |
0.409 |
|
|
|||||
|
Dose of dopamine (μg/kg/min) |
10.9 |
8.2 |
8.8 |
6.3 |
0.295 |
|
|
|||||
|
Initial creatinine (mg/dL) |
1.2 |
0.8 |
1.5 |
1.4 |
0.956 |
|
|
|||||
|
Initial urea (mg/dL) |
93.8 |
68.9 |
82.9 |
59.0 |
0.475 |
|
|
|||||
|
ALT (UI/L) |
174.7 |
171.0 |
209.5 |
776.3 |
0.355 |
|
|
|||||
|
Billirubine (mg/dL) |
3.1 |
4.0 |
1.5 |
1.4 |
0.218 |
|
|
|||||
|
Initial platelet (inicial) |
150.944 |
119.341 |
177.289 |
170.637 |
0.821 |
|
|
|||||
|
Platelet after 24 hours of CRRT |
89.000 |
72.960 |
122.068 |
111.964 |
0.254 |
|
|
|||||
|
Platelet after 48 hours of CRRT |
93.000 |
76.183 |
105.589 |
99.070 |
0.657 |
|
|
|||||
|
Maximum dose of heparin (UI/kg/h) |
14.7 |
13.1 |
15.2 |
10.3 |
0.351 |
|
|
|||||
|
Ultrafiltration rate (mL/kg/h) |
43.6 |
34.4 |
37.3 |
25.3 |
0.751 |
|
|
|||||
|
Circuit lifespan (h) |
47.5 |
61.5 |
41.9 |
36.9 |
0.638 |
|
|
|||||
|
Bleeding Number % |
Bleeding Number % |
||||
|
|
|||||
|
Age |
<12 m |
>12 m |
|||
|
|
|||||
|
9 |
11.8 |
9 |
9.4 |
0.600 |
|
|
|
|||||
|
Sex |
Male |
Female |
|||
|
|
|||||
|
9 |
8.7 |
9 |
13 |
0.366 |
|
|
|
|||||
|
Weight |
<10 kg |
>10 kg |
|||
|
|
|||||
|
9 |
10 |
9 |
11 |
0.835 |
|
|
|
|||||
|
Diagnoses |
Cardiopathies |
Rest of diagnoses |
|||
|
|
|||||
|
10 |
10.5 |
8 |
10.4 |
0.977 |
|
|
|
|||||
|
Mechanical ventilation |
Yes |
No |
|||
|
|
|||||
|
17 |
11.7 |
1 |
3.7 |
0.211 |
|
|
|
|||||
|
Vasoactive drugs |
Yes |
No |
|||
|
|
|||||
|
15 |
11 |
3 |
8.3 |
0.638 |
|
|
|
|||||
|
Initial MAP |
< 55 mmHg |
> 55 mmHg |
|||
|
|
|||||
|
11 |
17.5 |
7 |
6.6 |
0.034 |
|
|
|
|||||
|
Initial hypotension |
Sí |
No |
|||
|
|
|||||
|
10 |
14.3 |
8 |
8.3 |
0.241 |
|
|
|
|||||
|
Dose of adrenaline |
>0.6 μg/kg/min |
>0.6 μg/kg/min |
|||
|
|
|||||
|
5 |
14.7 |
13 |
11 |
0.561 |
|
|
|
|||||
|
Platelet |
<50.000 |
>50.000 |
|||
|
|
|||||
|
6 |
20 |
12 |
10.3 |
0.152 |
|
|
|
|||||
|
Platelet transfusion |
Sí |
No |
|||
|
|
|||||
|
14 |
18.9 |
4 |
4.1 |
0.002 |
|
|
|
|||||
|
CRRT technique |
Hemofiltration |
Hemodiafiltration |
|||
|
|
|||||
|
3 |
6.7 |
15 |
11.8 |
0.333 |
|
|
|
|||||
|
Filter surface |
<0.3 m2 |
>0.3 m2 |
|||
|
|
|||||
|
9 |
14.3 |
9 |
14.7 |
0.937 |
|
|
|
|||||
|
Maximum dose of heparin |
>10 U/kg/h |
<10 U/kg/h |
|||
|
|
|||||
|
7 |
8.4 |
11 |
12.4 |
0.401 |
|
|
|
|||||
|
Mortality |
Yes |
No |
|||
|
|
|||||
|
10 |
55.6% |
8 |
33.8% |
0.068 |
|
|
|
|||||
|
ALT = alanine transferase; CRRT = continuous renal replacement therapy; MAP = mean arterial pressure; PELOD = pediatric logistic organ dysfunction; PIM = pediatric index of mortality; PRIMS = pediatric risk of mortality; SD = standard deviation. |
|||||
|
Santiago et al. Critical Care 2009 13:R184 doi:10.1186/cc8172 |
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