Research
Effect of fluid resuscitation on mortality and organ function in experimental sepsis models
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* Corresponding author: Stephan M Jakob Stephan.Jakob@insel.ch
- † Equal contributors
1 Department of Anaesthesia and Pain Therapy, Inselspital, Bern University Hospital and University of Bern, CH-3010 Bern, Switzerland
2 Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, CH-3010 Bern, Switzerland
3 Department of Visceral and Transplant Surgery, Inselspital, Bern University Hospital and University of Bern, CH-3010 Bern, Switzerland
4 Department of Pediatric Surgery, Inselspital, Bern University Hospital and University of Bern, CH-3010 Bern, Switzerl
5 Institute of Pathology, University of Bern, Murtenstrasse 31, CH-3010 Bern, Switzerland
Critical Care 2009, 13:R186 doi:10.1186/cc8179
See related commentary by Groeneveld, http://ccforum.com/content/14/1/101
Published: 23 November 2009Additional files
Additional file 1:
A Word file containing a table that lists additional methods, along with related references.
Format: RTF Size: 82KB Download file
Additional file 2:
A Word file containing four tables. Table S1 lists acid-base-balance and oxygen transport parameters. Table S2 gives hepatic mitochondrial ATP/ADP and ADP/oxygen ratios and calculated maximal ATP production obtained from mitochondrial respiration analysis. Table S3 lists skeletal muscle ATP content obtained from biopsies and muscle ATP/ADP ratios. Table S4 gives details of regional blood flows.
Format: RTF Size: 301KB Download file
Additional file 3:
A PDF file containing six figures. Figure S1 is a comparison of complex I- and II-dependent hepatic mitochondrial respiration between the groups. Figure S2 shows lactate/pyruvate ratios in the hepatic vein. Figure S3 is a comparison of complex I- and II-dependent muscle mitochondrial respiration between the groups. Figure 4 shows lung histology: colloid plaques. Figure S5 shows lung histology: atelectasis. Figure S6 shows liver histology.
Format: PDF Size: 3.3MB Download file
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