Table 4

Laboratory parameters

Variable

Group

N

Baseline

End

Interactions

P

Creatinine kinase - MB (U/L)

Time × volume effect:

0.006

Control 10 ml/kg

8

0.9 ± 0.1

1.0 ± 0.2

Control 20 ml/kg

8

0.9 ± 0.1

1.2 ± 0.2

ANOVArm high-volume:

0.001

Endotoxin 10 ml/kg

8

1.0 ± 0.2

1.0 ± 0.2

Endotoxin 20 ml/kg

7

1.0 ± 0.2

1.1 ± 0.3

Peritonitis 10 ml/kg

8

1.1 ± 0.2

1.1 ± 0.3

Peritonitis 20 ml/kg

8

0.8 ± 0.3

1.3 ± 0.2

Creatinine (μmol/L)

Time × model effect:

Time × volume effect:

0.014

0.029

Control 10 ml/kg

8

87 ± 18

78 ± 17

ANOVArm Control:

0.007

Control 20 ml/kg

8

99 ± 13

74 ± 24

ANOVArm high-volume:

0.04

Endotoxin 10 ml/kg

8

86 ± 21

79 ± 16

Endotoxin 20 ml/kg

7

85 ± 15

74 ± 10

Peritonitis 10 ml/kg

8

81 ± 10

114 ± 31

Peritonitis 20 ml/kg

8

82 ± 17

76 ± 36

ALAT (U/L)

Time × volume effect:

0.001

Control 10 ml/kg

8

18.1 ± 4.3

14.8 ± 4.5

Control 20 ml/kg

8

20.5 ± 10.5

11.3 ± 10.6

ANOVArm high-volume:

0.001

Endotoxin 10 ml/kg

8

17 ± 5.2

15.1 ± 4.3

Endotoxin 20 ml/kg

7

19 ± 5.7

11.4 ± 2.4

Peritonitis 10 ml/kg

8

16.9 ± 6.4

16.7 ± 11.2

Peritonitis 20 ml/kg

8

19.5 ± 9.2

11.3 ± 5

ASAT (U/L)

Control 10 ml/kg

8

84 ± 31

60 ± 27

Control 20 ml/kg

8

114 ± 57

76 ± 23

Endotoxin 10 ml/kg

8

96 ± 23

86 ± 44

Endotoxin 20 ml/kg

7

136 ± 84

117 ± 23

Peritonitis 10 ml/kg

8

104 ± 43

129 ± 88

Peritonitis 20 ml/kg

8

101 ± 50

100 ± 55

Values are mean ± standard deviation. ALAT = alanine aminotransferase; ASAT = aspartate aminotransferase.

Brandt et al. Critical Care 2009 13:R186   doi:10.1186/cc8179