Table 1 |
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|
Blood and plasma levels of biochemical variables during the pre-sepsis period, immediately before treatment, and then at 2, 4 and 6 hours of Ang II or vehicle infusion (n = 6 in both groups) |
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|
Variables |
Treatment |
Pre-sepsis |
0 h |
2 h |
4 h |
6 h |
|
|
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|
Ph |
Ang II |
7.489 ± 0.025 |
7.518 ± 0.036 |
7.509 ± 0.049 |
7.518 ± 0.055 |
7.517 ± 0.060 |
|
Vehicle |
7.449 ± 0.075 |
7.496 ± 0.054 |
7.520 ± 0.055 |
7.506 ± 0.049 |
7.496 ± 0.042 |
|
|
PaCO2 (Torr (kPa)) |
Ang II |
34.9 ± 1.9 (4.65 ± 0.25) |
31.0 ± 3.4* (4.13 ± 0.45) |
34.5 ± 4.0 (4.60 ± 0.53) |
35.2 ± 3.8 (4.69 ± 0.51) |
36.0 ± 3.6 (4.80 ± 0.48) |
|
Vehicle |
33.8 ± 2.3 (4.37 ± 0.31) |
31.6 ± 2.3* (4.21 ± 0.31) |
36.0 ± 6.3 (4.80 ± 0.84) |
36.0 ± 6.8 (4.80 ± 0.91) |
37.3 ± 10.3 (4.97 ± 1.37) |
|
|
Pa O2 (Torr (kPa)) |
Ang II |
97.5 ± 12.0 (13.0 ± 1.6) |
85.5 ± 3.5* (11.4 ± 0.5) |
89.0 ± 6.8 (11.9 ± 0.9) |
87.6 ± 10.3 (11.7 ± 1.4) |
84.9 ± 10.0 (11.3 ± 1.3) |
|
Vehicle |
97.8 ± 5.1 (13.0 ± 0.7) |
92.3 ± 10.2* (12.4 ± 1.4) |
83.4 ± 10.4 (11.1 ± 1.4) |
89.3 ± 7.9 (11.9 ± 1.1) |
83.1 ± 9.1 (11.1 ± 1.2) |
|
|
HCO3- (mmol/l) |
Ang II |
26.3 ± 1.6 |
24.9 ± 1.5 |
27.2 ± 2.4 |
28.4 ± 2.9 |
29.0 ± 2.8 |
|
Vehicle |
23.3 ± 3.7 |
24.3 ± 2.3 |
29.2 ± 5.1 |
28.4 ± 6.9 |
28.7 ± 8.8 |
|
|
BE (mmol/l) |
Ang II |
3.4 ± 1.6 |
2.7 ± 1.4 |
4.4 ± 2.6 |
5.5 ± 3.0 |
5.9 ± 3.1 |
|
Vehicle |
0.0 ± 4.6 |
1.6 ± 2.7 |
6.2 ± 4.7 |
5.2 ± 6.1 |
5.3 ± 7.5 |
|
|
K+ (mmol/l) |
Ang II |
4.3 ± 0.2 |
4.1 ± 0.4 |
4.1 ± 0.6 |
4.0 ± 0.7 |
3.9 ± 0.7 |
|
Vehicle |
4.0 ± 0.4 |
3.9 ± 0.3 |
4.1 ± 0.3 |
4.3 ± 0.4 |
4.2 ± 0.4 |
|
|
Na+ (mmol/l) |
Ang II |
142.3 ± 3.8 |
143.3 ± 3.2 |
143.2 ± 2.5 |
142.0 ± 2.5 |
141.3 ± 2.4 |
|
Vehicle |
143.2 ± 1.9 |
143.8 ± 3.4 |
144.0 ± 4.0 |
144.0 ± 4.6 |
144.0 ± 4.6 |
|
|
Ca2+ (mmol/l) |
Ang II |
1.2 ± 0.1 |
1.1 ± 0.1* |
1.1 ± 0.1 |
1.0 ± 0.1 |
1.0 ± 0.2 |
|
Vehicle |
1.2 ± 0.1 |
1.1 ± 0.1* |
1.1 ± 0.1 |
1.1 ± 0.0 |
1.2 ± 0.0 |
|
|
Cl- (mmol/l) |
Ang II |
109.7 ± 3.3 |
111.5 ± 5.9 |
106.8 ± 3.4 |
105.0 ± 3.7 |
103.3 ± 4.1 |
|
Vehicle |
108.8 ± 2.1 |
108.0 ± 3.2 |
108.0 ± 3.6 |
107.8 ± 4.3 |
108.5 ± 4.2 |
|
|
Lactate (mmol/l) |
Ang II |
0.6 ± 0.2 |
2.1 ± 1.4* |
2.1 ± 1.6 |
1.8 ± 1.2 |
1.7 ± 1.4 |
|
Vehicle |
0.5 ± 0.1 |
1.9 ± 1.2* |
1.8 ± 1.3 |
1.5 ± 1.3 |
1.4 ± 1.4 |
|
|
HB (g/dl) |
Ang II |
9.9 ± 1.2 |
10.8 ± 1.0 |
10.1 ± 1.3 |
9.8 ± 0.9 |
9.9 ± 1.1 |
|
Vehicle |
9.7 ± 1.6 |
10.2 ± 1.1 |
9.9 ± 1.1 |
9.6 ± 1.1 |
9.6 ± 1.0 |
|
|
|
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|
Results are mean ± standard deviation. There were no significant differences between the Ang II and vehicle groups. * statistical difference between pre-sepsis period and sepsis control period. Ang II = angiotensin II; BE = base excess; HB = hemoglobin; PaCO2 = partial pressure of arterial carbon dioxide; PaO2 = partial pressure of arterial oxygen. |
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|
Wan et al. Critical Care 2009 13:R190 doi:10.1186/cc8185 |
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