Table 4 |
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|
Comparison of baseline markers of coagulation and circuit life between patients with SOFA score of 10 or less (median) and those with SOFA score of more than 10 |
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|
SOFA score |
≤10 n = 7 |
>10 n = 7 |
P value |
≤10 n = 7 |
>10 n = 7 |
P value |
|
|
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|
Baseline (arterial) |
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|
|
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|
antithrombin (%) |
58 (34-79) |
52 (36-86) |
0.24 |
|||
|
|
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|
anti-Xa (IU/ml) |
0.06 (0.00-0.15) |
0.11 (0.00-0.55) |
0.94 |
|||
|
|
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|
PTT (sec) |
11.4 (11.0-11.5) |
12.0 (11.4-24.2) |
0.004 |
|||
|
|
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|
aPTT (sec) |
24.3 (20.3-35.1) |
36.2 (27.5-95.3) |
0.02 |
|||
|
|
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|
Platelets (109/L) |
143 (96-221) |
179 139-267) |
0.54 |
|||
|
|
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|
ETPTlag (sec) |
19.7 (18.4-22.1) |
23.0 (18.6-31.0) |
0.24 |
|||
|
|
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|
ETPTmax (sec) |
54.8 (51.6-55.7) |
48.5 (39.6-54.8) |
0.37 |
|||
|
|
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|
ETPCmax |
139 (113-153) |
97 (61-119) |
0.05 |
|||
|
|
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|
ETPAUC (mA) |
359 (246-437) |
187 (118-279) |
0.08 |
|||
|
|
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|
F1+2 (pmol/L) |
216 (125-288) |
314 (165-689) |
0.81 |
|||
|
|
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|
TAT (μg/L) |
7.4 (5.2-9.0) |
20.7 (15.1-29.0) |
0.008 |
|||
|
|
||||||
|
D-dimers (μg/ml) |
9 (1.5-29.8) |
14 (4.3-43.8) |
0.47 |
|||
|
|
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|
circuit life (h) |
32 (25-39) |
12 (4-24) |
0.002 |
|||
|
|
||||||
|
during CVVH and nadroparin infusion (arterial) |
during CVVH (postfilter) |
|||||
|
|
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|
anti-Xa (IU/ml) |
0.28 (0.20-0.45) |
0.16 (0.10-0.38) |
0.008 |
0.53 (0.35-0.71) |
0.32 (0.24-0.54) |
0.003 |
|
|
||||||
|
PTT (sec) |
11.3 (11.0-11.8) |
11.4 (10.8-14.6) |
0.18 |
10.7 (10.2-11.2) |
10.7 (10.3-12.4) |
0.10 |
|
|
||||||
|
aPTT (sec) |
26 (21.9-32.2) |
28.6 (27.1-36.6) |
0.001 |
25.9 (21.7-30.8) |
28.7 (25-5.32.5) |
0.006 |
|
|
||||||
|
Platelets (109/L) |
140 (116-196) |
160 (119-251) |
0.65 |
176 (138-217) |
193 (154-281)) |
0.85 |
|
|
||||||
|
ETPTlag (sec) |
20.3 (16.7-22.3) |
18.8 (15.8-23.8) |
0.61 |
17.1 (13.0-21.3) |
18.3 (16.1-24.2) |
0.06 |
|
|
||||||
|
ETPTmax (sec) |
45.8 (40.4-54.7) |
50.8 (42.8-60.2) |
0.13 |
40.1 (34.7-43.7) |
45.8 (36.6-52.6) |
0.04 |
|
|
||||||
|
ETPcmax (mA/min) |
119 (89-146) |
109 (89-132) |
0.13 |
145 (111-183) |
123 (97-134) |
0.003 |
|
|
||||||
|
ETPAUC (mA) |
267 (167-350) |
244 (161-294) |
0.24 |
218 (87-307) |
169 (76-268) |
0.30 |
|
|
||||||
|
F1+2 (pmol/L) |
202 (134-330) |
301 (219-500) |
0.88 |
307 (157-429) |
471 (314-793) |
0.78 |
|
|
||||||
|
TAT (μg/L) |
5.3 (4.8-7.4) |
16.2 (7.1-36.8) |
< 0.001 |
7.9 (6.4-13.4) |
27 (13.3-58.4) |
< 0.001 |
|
|
||||||
|
D-dimers (μg/ml) |
7.6 (2.1-21.2) |
19.7 (4.4-37.6) |
0.004 |
10.7 (3.1-34.8) |
28.6 (7.3-51.4) |
0.002 |
|
|
||||||
|
Values in median (interquartile range). Values during CVVH are medians of all samples. Postfilter values are actual values, not corrected for hemoconcentration. aPTT = activated thromboplastin time; CVVH = continuous venovenous hemofiltration; ETP = endogenous thrombin potential; ETPAUC = area under the curve of the thrombin generation curve; ETPCmax = maximal activity of ETP; ETPTlag = ETP lag time = ETPTmax = time to max ETP activity; F1+2 = prothrombin fragment; PTT = prothrombin time; SOFA = Sequential Organ Failure Assessment; TAT = thrombin-antithrombin complexes. |
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|
Oudemans-van Straaten et al. Critical Care 2009 13:R193 doi:10.1186/cc8191 |
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