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This article is part of the supplement: 29th International Symposium on Intensive Care and Emergency Medicine

Poster presentation

RIFLE classification can predict hospital mortality of critically ill patients

HY Xu1, JM Peng1, ZR Mao2, L Weng1, XY Hu1 and B Du1

Author Affiliations

1 Peking Union Medical College Hospital, Beijing, PR China

2 First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Henan, PR China

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Critical Care 2009, 13(Suppl 1):P264 doi:10.1186/cc7428


The electronic version of this article is the complete one and can be found online at: http://ccforum.com/content/13/S1/P264


Published:13 March 2009

© 2009 Xu et al; licensee BioMed Central Ltd.

Introduction

The Acute Dialysis Quality Initiative group has proposed the RIFLE (Risk–Injury–Failure–Loss–End-stage renal disease) classification to assess acute kidney injury (AKI). We sought to evaluate the incidence of AKI in critically ill patients according to the RIFLE classification and the correlation between RIFLE class and hospital mortality.

Methods

We performed a retrospective cohort study applying the RIFLE classification on 1,138 patients admitted to the ICU during a 2-year period.

Results

According to the RIFLE classification, 376 patients (33%) had AKI during their ICU stay. When assessing the maximum RIFLE class, 209 (18.3%) patients were classified Risk, 63 (5.5%) as Injury and 104 (6.3%) as Failure. Female (OR = 1.53; 95% CI = 1.18 to 1.98; P = 0.001), nonsurgical admission (OR = 1.32; 95% CI = 1.01 to 1.70; P = 0.039), APACHE II on admission above 25 (OR = 1.99; 95% CI = 1.06 to 3.76; P = 0.033), sepsis on admission (OR = 2.20; 95% CI = 1.01 to 4.79; P = 0.046) and chronic organ dysfunction (OR = 1.65; 95% CI = 1.09 to 2.50; P = 0.017) were independent risk factors for AKI. Patients with progressive RIFLE classification had increased hospital mortality, with Risk 13.9%, Injury 22.2% and Failure 47%, as compared with 7.9% (P < 0.001) among patients without AKI. Furthermore, the RIFLE class Failure was an independent predictor of 3-month hospital mortality (OR = 2.37; 95% CI = 1.23 to 4.54; P = 0.009) in addition to organ failure on admission (OR = 4.60; 95% CI = 2.31 to 9.18; P < 0.001), use of vasopressor (OR = 2.34; 95% CI = 1.09 to 5.00; P = 0.028), and APACHE II score on admission (OR = 1.160; 95% CI = 1.11 to 1.21; P < 0.001).

Conclusion

Patients with increasing RIFLE classification had significant elevated hospital mortality. Maximum RIFLE class Failure was independently associated with 3-month hospital mortality.

References

  1. Bellomo R, et al.: Acute renal failure-definitions, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.

    Crit Care 2004, 8:R204-R212. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  2. Hoste EA, et al.: RIFLE criteria for acute kidney injury are associated with hospital mortality in critical ill patients: a cohort analysis.

    Crit Care 2006, 10:R73-R83. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL