Table 3 |
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|
Univariate and multivariate logistic regression analysis of risk factors associated with development of acute lung injury |
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|
Lung injury (n = 12) |
No lung injury (n = 138) |
P value univariate analysis |
P value multivariate analysis |
|
|
|
||||
|
Age (years) |
63.5 (54.3-78.3) |
63.0 (48.8-74.0) |
0.41 |
- |
|
Male gender (n, %) |
9 (75%) |
90 (65%) |
0.49 |
- |
|
APACHE-II score |
19 (15-23) |
20 (15-27) |
0.82 |
- |
|
LIS |
1.5 (1.25-2.0) |
1.25 (0.75-1.75) |
0.03 |
- |
|
ALI-risk factor (n, %) |
10 (83%) |
82 (59%) |
0.10 |
0.14 |
|
Number of transfused blood products (median, IQR) |
0 (0-13) |
0 (0-2) |
0.01 |
- |
|
Oxygenation Index |
5.2 (4.3-6.8) |
3.9 (2.7-5.5) |
0.04 |
- |
|
PaO2/FiO2 |
34 (26-41) |
(35 (28-45) |
0.46 |
- |
|
Conventional-tidal-volume group |
10 (83%) |
64 (46%) |
0.01 |
0.007 |
|
PEEP level (cm H2O) |
10 (8-12) |
5 (5-9) |
0.001 |
0.001 |
|
IL-6 level in lavage fluid (median with IQR, pg/ml) |
592 (148-1,321) |
226 (23-765) |
0.04 |
- |
|
IL-6 level in plasma (pg/ml) |
79 (25-565) |
48 (19-145) |
0.13 |
- |
|
TNF-α level in lavage fluid (median with IQR, pg/ml) |
7.2 (1.0-121) |
1.3 (0-30.6) |
0.11 |
- |
|
IL-1β level in lavage fluid (median with IQR, pg/ml) |
9.0 (0.0-96.7) |
42.4 (4.2-281) |
0.32 |
- |
|
|
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|
APACHE-II = acute physiology and chronic health evaluation-II; LIS = lung injury score. Data are expressed as medians with interquartile range or as number with percentage. Underlying risk factors in patients in whom lung injury developed were sepsis (n = 4), shock (n = 1), trauma (n = 1), drug overdose (n = 1), and multiple blood transfusions (n = 1) in the conventional-tidal-volume group, and pneumonia (n = 1) and shock (n = 1) in the lower-tidal-volume group. |
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|
Determann et al. Critical Care 2010 14:R1 doi:10.1186/cc8230 |
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