Table 3

Temporal changes observed in 13 biguanide-intoxicated patients with central venous oxygen saturation (but not cardiac index) monitoring

n

Day 1

Day 2

Day 3

Day 4

P

pH

13

7.14 ± 0.17

7.36 ± 0.10*

7.45 ± 0.09*

7.43 ± 0.06*

<0.001

Lactate (mM)

13

12 ± 6

5 ± 8*

2 ± 1*

2 ± 1*

<0.001

C(a-v)O₂

(ml O₂/100 ml)

12

2.5 ± 1.1

3.1 ± 1.0

3.4 ± 0.8

4.2 ± 1.2*

<0.05

SvO₂ (%)

12

79 ± 10

75 ± 10

73 ± 6*

66 ± 7*

0.01

OEI (%)

12

20 ± 10

24 ± 10

25 ± 7

33 ± 7*

0.01

C(v-a)CO₂

(ml CO₂/100 ml)

8

2.4 ± 1.6

2.8 ± 1.2

3.6 ± 0.9

5.5 ± 1.9

0.16

RASS

13

-1 (-4-0)

0 (-3-0)

0 (-1-0)

-1 (-3-0)

0.05

On MV (%)

13

31

42

27

38

0.89

HR

12

87 ± 17

88 ± 15

91 ± 14

88 ± 8

0.10

SOFA

13

9 ± 2

8 ± 3

6 ± 3*

7 ± 3*

<0.001

Catecholamine use (SOFA sub score)

13

3 ± 2

3 ± 2

2 ± 2*

2 ± 2*

<0.01

BT (°C)

10

35.8

(35.0-36.3)

36.8

(36.4-37.3)

37.0

(36.7-37.5)*

36.9

(36.6-37.4)

<0.05

Results of repeated-measures analysis of variance and chi-squared test are reported in the right column. Data significantly different from day 1 on post-hoc comparison are indicated as *. n is the number of patients with each specific variable monitored on day 1.

BT, body temperature; C(a-v)O₂, arterio-venous difference in oxygen content; C(v-a)CO₂, veno-arterial difference in carbon dioxide content; HR, heart rate; MV, mechanical ventilation; OEI, oxygen extraction index; RASS, Richmond Agitation Sedation Score; SOFA, Sequential Organ Failure Assessment; SvO₂, central venous oxygen saturation.

Protti et al. Critical Care 2010 14:R22   doi:10.1186/cc8885