Table 1 |
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Baseline characteristics of patients with and without sepsis |
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Patients with sepsis |
Patients without sepsis |
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Variable |
DEX (n = 31) |
LZ (n = 32) |
DEX (n = 20) |
LZ (n = 19) |
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|
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Age |
60 (46 to 65) |
58 (44 to 66) |
61 (50 to 68) |
60 (52 to 67) |
|
Males |
58% |
41% |
57% |
53% |
|
APACHE II |
30 (26 to 34) |
29 (24 to 32) |
27 (20 to 31) |
25 (20 to 30) |
|
SOFA score |
10 (9 to13) |
9 (8 to 12) |
9 (8 to 12) |
8 (7 to 9) |
|
IQCODE at enrollment |
3 (3 to 3) |
3 (3 to 3) |
3 (3 to 3) |
3 (3 to 3) |
|
Medical ICU |
77% |
81% |
62% |
47% |
|
Surgical ICU |
23% |
19% |
38% |
53% |
|
Pre-enrollment lorazepam (mg) |
1.5 (0 to 5) |
0 (0 to 4) |
0 (0 to 4) |
0 (0 to 2) |
|
Enrollment RASS |
-3 (-4 to -2) |
-4 (-4 to -3) |
-3 (-4 to 0) |
-3 (-4 to -1) |
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SIRS criteria |
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Temperature (Fahrenheit) |
37.5 (37 to 38.3) |
38 (37.2 to 38.6) |
36.7 (35.8 to 37.8) |
37.2 (36.2 to 38.3) |
|
White blood count (103/μL) |
12.5 (6.6 to 21.7) |
12.5 (7.7 to 18.8) |
14.6 (8.9 to17.9) |
10 (7.5 to14) |
|
Systolic BP (mm Hg) |
88 (78 to 100) |
83 (79 to 100) |
92 (90 to 100) |
90 (80 to110) |
|
Heart rate (per minute) |
113 (100 to 134) |
119 (96 to 130) |
80 (65 to123) |
107 (99 to 126) |
|
Respiratory rate |
26 (20 to 33) |
33 (27 to 39) |
20 (15 to24) |
24 (20 to28) |
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Organ dysfunction at enrollment |
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PaO2/FiO2 ratio |
128 (105 to 209) |
126 (94 to 198) |
127 (72 to 211) |
145 (81 to 223) |
|
Creatinine (mg/dL) |
1.7 (0.8 to 2.9) |
1.0 (0.8 to 1.8) |
1.2 (1.0 to 1.7) |
0.9 (0.8 to 1.4) |
|
Vasopressors |
32% |
56% |
19% |
5% |
|
Bilirubin (mg/dL) |
0.5 (0.4 to 0.8) |
0.9 (0.4 to 1.8) |
0.6 (0.5 to 1.6) |
0.6 (0.4 to 1.1) |
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Platelets (103/μL) |
176 (61 to 304) |
183 (107 to 266) |
186 (101 to242) |
145 (114 to 242) |
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Median (interquartile range) unless otherwise noted. APACHE II, Acute Physiology and Chronic Health Evaluation II; BP, Blood pressure; DEX, dexmedetomidine; FiO2, fraction of inspired oxygen; IQCODE, Informant Questionnaire on Cognitive Decline in the Elderly; LZ, lorazepam; PaO2, partial pressure of arterial oxygen; RASS, Richmond Agitation-Sedation Scale; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment. |
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Pandharipande et al. Critical Care 2010 14:R38 doi:10.1186/cc8916 |
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