Table 3

Hemodynamic parameters in patients with and without sepsis

Patients with sepsis

Patients without sepsis

Hemodynamic variable*

DEX

(n = 31)

LZ

(n = 31)

P value

DEX

(n = 20)

LZ

(n = 19)

P value

Number of days on vasoactive drugs

1 (1)

2 (2)

0.08

1.5 (2.2)

0.3 (0.9)

0.08

Average daily number of vasoactive drugs

1.1 (0.2)

1.6 (0.5)

0.004

1.6 (0.9)

1 (0)

0.2

Ever vasoactive drugs increased

26%

47%

0.08

33%

16%

0.2

Sinus bradycardia (<60 beats/min)

13%

6%

0.4

24%

0%

0.02

Sinus tachycardia (>100 beats/min)

81%

84%

0.7

52%

53%

1

Mean (standard deviation) unless otherwise noted.

DEX, dexmedetomidine; LZ, lorazepam.

*Measured during 120-hour study drug protocol, except for sinus bradycardia and sinus tachycardia, which are measured during entire study.

Pandharipande et al. Critical Care 2010 14:R38   doi:10.1186/cc8916