Airspace and lung tissue neutrophils. Broncho-alveolar lavage (BAL) neutrophil count (top) reflects airspace neutrophils. Myeloperoxidase (MPO) activity (bottom) was used to detect lung tissue neutrophil infiltration. Both inflammatory markers were reduced by activated protein C (APC), suggesting less lung injury (data expressed as mean ± standard deviation; * denotes P < 0.05 for comparison with LVt-30 min; One-way analysis of variance or Kruskal-Wallis test with post-hoc analysis by Dunnett's test).
Maniatis et al. Critical Care 2010 14:R70 doi:10.1186/cc8976