Email updates

Keep up to date with the latest news and content from Critical Care and BioMed Central.

Open Access Highly Accessed Research

Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study

Moritz Wyler von Ballmoos1, Jukka Takala1, Margareta Roeck1, Francesca Porta1, David Tueller1, Christoph C Ganter1, Ralph Schröder1, Hendrik Bracht1, Bertram Baenziger2 and Stephan M Jakob1*

Author Affiliations

1 Department of Intensive Care Medicine, Bern University Hospital and University of Bern (Inselspital), Freiburgstrasse 10, 3010 Bern, Switzerland

2 Department of Anesthesiology and Pain Therapy, Bern University Hospital and University of Bern (Inselspital), Freiburgstrasse 10, 3010 Bern, Switzerland

For all author emails, please log on.

Critical Care 2010, 14:R111  doi:10.1186/cc9060


See related commentary by Madger, http://ccforum.com/content/14/5/197

The electronic version of this article is the complete one and can be found online at: http://ccforum.com/content/14/3/R111


Received:29 October 2009
Revisions received:15 March 2010
Accepted:11 June 2010
Published:11 June 2010

© 2010 Wyler von Ballmoos, et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction

Pulse-pressure variation (PPV) due to increased right ventricular afterload and dysfunction may misleadingly suggest volume responsiveness. We aimed to assess prediction of volume responsiveness with PPV in patients with increased pulmonary artery pressure.

Methods

Fifteen cardiac surgery patients with a history of increased pulmonary artery pressure (mean pressure, 27 ± 5 mm Hg (mean ± SD) before fluid challenges) and seven septic shock patients (mean pulmonary artery pressure, 33 ± 10 mm Hg) were challenged with 200 ml hydroxyethyl starch boli ordered on clinical indication. PPV, right ventricular ejection fraction (EF) and end-diastolic volume (EDV), stroke volume (SV), and intravascular pressures were measured before and after volume challenges.

Results

Of 69 fluid challenges, 19 (28%) increased SV > 10%. PPV did not predict volume responsiveness (area under the receiver operating characteristic curve, 0.555; P = 0.485). PPV was ≥13% before 46 (67%) fluid challenges, and SV increased in 13 (28%). Right ventricular EF decreased in none of the fluid challenges, resulting in increased SV, and in 44% of those in which SV did not increase (P = 0.0003). EDV increased in 28% of fluid challenges, resulting in increased SV, and in 44% of those in which SV did not increase (P = 0.272).

Conclusions

Both early after cardiac surgery and in septic shock, patients with increased pulmonary artery pressure respond poorly to fluid administration. Under these conditions, PPV cannot be used to predict fluid responsiveness. The frequent reduction in right ventricular EF when SV did not increase suggests that right ventricular dysfunction contributed to the poor response to fluids.

Introduction

A main goal of cardiovascular support is to restore and maintain sufficient cardiac output. Whereas prompt treatment of hypovolemia is necessary to sustain tissue perfusion, too much volume administration may result in edema formation and impaired tissue perfusion, with consequent organ dysfunction and increased risk of death [1-5]. Because blood volume cannot reliably be assessed clinically [6-11], the hemodynamic response to a volume challenge is commonly used to guide fluid management. Pulse-pressure variation (PPV), reflecting variations in stroke volume, has been advocated to discriminate between patients whose stroke volume increases in response to volume expansion and those who do not respond [12]. Conversely, PPV due to increased right ventricular afterload and right ventricular dysfunction may misleadingly suggest volume responsiveness [13-15]. Increased pulmonary artery pressure and moderate or transient right ventricular dysfunction are not rare in intensive care patients requiring hemodynamic support. For example, transient right ventricular dysfunction occurs after cardiac surgery [16,17], and high pulmonary artery pressures and dysfunction of both ventricles are common in septic shock [18,19].

We hypothesized that PPV does not predict volume responsiveness in the presence of increased pulmonary artery pressure, and that right ventricular dysfunction may contribute to this. To test this hypothesis, we measured PPV and the hemodynamic response to clinically indicated fluid challenges in patients with septic shock and in postoperative cardiac surgery patients with increased pulmonary artery pressure.

Materials and methods

The study was approved by the Ethics Committee of the Canton of Bern. Written informed consent was obtained from 20 cardiac surgery patients with a preoperative history of increased pulmonary artery pressure, and from both an independent physician and a close family member of 10 patients in septic shock.

Inclusion criteria

Cardiac surgery patients were included if they had an increased pulmonary artery pressure, as estimated during a preoperative echocardiogram (peak pulmonary artery pressure, ≥40 mm Hg) or a history of right ventricular myocardial infarction or right heart failure, and a clinical indication for a pulmonary artery catheter perioperatively, as judged by the patient's cardiac anesthetist, who was not involved in the study.

Patients with septic shock had septic shock defined as three of four systemic inflammatory-response syndrome criteria: (a) hyperthermia (≥38°C) or hypothermia (≤5.6°C); (b) tachycardia (heart rate, ≥90 beats/min); (c) tachypnea (respiratory rate, ≥20 breaths/min) or need for mechanical ventilation; and (d) leukocytosis (white blood cell count, ≥10 × 103 per microliter) or leucopenia (white blood cell count, ≤3 × 103 per microliter), and mean blood pressure < 60 mm Hg, despite volume resuscitation, or need for vasopressors to keep mean blood pressure ≥60 mm Hg. In addition, the patient had to have a clinically indicated pulmonary artery catheter ordered by the clinical team treating the patient.

All patients were receiving controlled mechanical ventilation with a tidal volume of 8-10 ml/kg and a ventilatory frequency that resulted in a normal arterial pCO2.

Exclusion criteria

Patients with severe mitral valve insufficiency were excluded.

Measurement of cardiac output, stroke volume, right-ventricular end-diastolic volume and ejection fraction, and blood pressures

A volumetric pulmonary artery catheter (Edwards Combo V Catheter, Edwards Lifesciences LLC, Irvine, CA, USA) and cardiac output monitor (Vigilance, Edwards Lifesciences) were used to measure cardiac output, pulmonary artery pressures, and right ventricular ejection fraction and end-diastolic volume. Systemic and pulmonary artery and central venous pressures were recorded with quartz pressure transducers and displayed continuously on a multimodular monitor (Merlin; Hewlett Packard, Geneva, Switzerland). The pressure transducers were zeroed to the level of the heart. Heart rate was measured from the electrocardiogram (ECG), which was continuously monitored. Only the variables routinely available by using the patient-monitoring devices were made available to and were used by the clinical team.

For the study purposes, the intravascular pressures and heart rate were also recorded at 50 Hz on a computer using AcqKnowledge software (version 3.8.1; Biopac Systems, Goleta, CA, USA), and variables from the continuous cardiac-output monitor/mixed venous oxygen-saturation monitor (Vigilance; Edwards Lifesciences) were recorded with a frequency of 0.5 Hz on the same computer by using the serial output from the monitor and a proprietary research software (Edwards Lifesciences) and analyzed off-line.

Study protocol

If the intensivist in charge of the care of the patient considered a volume challenge to be clinically indicated, 200 ml of hydroxyethyl starch (Voluven 6%, Fresenius Kabi AG, Stans, Switzerland) were infused over a 10-minute period. The study personnel performed hemodynamic measurements immediately before and between 15 and 20 minutes after the end of the volume challenge. The ventilator airway-pressure signal on the ventilator screen and the end-tidal CO2 signal displayed on the monitor were visually observed, and fluid challenges were included only if signs of spontaneous respiratory efforts were absent.

The semicontinuous cardiac-output values were obtained from the values captured from the serial port of the device (equivalent to STAT mode). For each variable, artifact-free 2-minute mean values were used for analysis. The main reason(s) that the clinician in charge of the patient considered the fluid challenge necessary was recorded.

Assessment of pulse-pressure variation

PPV analysis was performed on the arterial pressure curve of 20 consecutive heart beats by using the following algorithm (20): PPV (%) = 100 × (Ppmax - Ppmin)/((Ppmax + Ppmin)/2). Only recordings made during volume-controlled mechanical ventilation were analyzed. Each beat-to-beat tracing of intravascular central venous and pulmonary artery pressures was independently assessed by two senior investigators (SJ and JT, blinded for the response to volume challenge) to verify the absence of any spontaneous respiratory activity.

Evaluation of volume response

Changes in stroke volume (SV) were used to define response to volume challenge. An increase in stroke volume exceeding 10% after the volume challenge was considered a positive response. The volume challenge should increase the SV as a result of acutely increased preload in a heart operating on the steep portion of the cardiac-function curve [20,21]. The results were therefore analyzed in two ways: including all volume challenges, and including only those resulting in an increase in central venous pressure (CVP) of > 1 mm Hg. The directional changes in right ventricular ejection fraction and end-diastolic volume in response to volume challenge were separately analyzed for the responders and nonresponders.

Statistics

To assess differences in proportions between groups of patients, Fisher's Exact test was used. The effect of a volume challenge on hemodynamic variables was assessed with ANOVA for repeated measurements by using one within-subject factor (hemodynamic variable) and two between-subject factors (responder versus nonresponder with respect to stroke volume, and diagnosis). With this approach, a different response of a given hemodynamic variable in responders versus nonresponders is indicated by a fluid challenge-responder interaction, and a difference in the behavior of responders versus nonresponders in the two patient groups is indicated by a fluid challenge/responder/diagnosis interaction. Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive value of PPV. Best predictive threshold was defined as the highest sum of sensitivity and specificity. Data are presented as median and interquartile range (demographics and ventilator settings), as percentage (proportional data), and as mean ± SD (hemodynamic variables). A P value < 0.05 was considered statistically significant.

Results

Four cardiac surgery patients and two septic shock patients were excluded from the data analysis because of cardiac dysrhythmia during the study. Further, one cardiac surgery and one septic shock patient were excluded because of continuous spontaneous respiratory activity. Accordingly, 15 postoperative cardiac surgery patients and seven patients with septic shock were analyzed. Patient data are indicated in Table 1.

Table 1. Patient characteristics and ventilator settings during the study

Sixty-nine fluid challenges were performed (44 in cardiac surgery patients and 25 in septic shock patients; one to eight per patient). The most common indications for fluid challenge were hypotension and peripheral vasoconstriction (Additional file 1).

Additional file 1. Clinical indications for fluid challenges. A table listing clinical indications for fluid challenges.

Format: DOC Size: 35KB Download file

This file can be viewed with: Microsoft Word ViewerOpen Data

Baseline hemodynamics (before the first fluid challenge) were similar in cardiac surgery and septic patients (Table 2). Overall, the fluid challenges increased stroke volume, CVP, pulmonary artery occlusion pressure (PAOP), and systemic and pulmonary arterial pressures (Table 3).

Table 2. Baseline hemodynamic characteristics

Table 3. Hemodynamic changes in patients with (responders) and without (nonresponders) increase in stroke volume after a volume challenge

Nineteen (28%) of the 69 fluid challenges increased SV in 12 patients: in cardiac surgery patients, 12 of 44 fluid challenges (27%; seven patients) and in septic shock, seven of 25 fluid challenges (28%; five patients). If only fluid challenges that increased CVP by > 1 mm Hg are considered (31 of 44 fluid challenges in cardiac surgery and 22 of 25 in septic shock), SV increased in 15 (28%) of 53 fluid challenges.

Pulse-pressure variation and volume responsiveness

PPV did not predict an increase in SV. The area under the ROC curve (AUC; Figures 1,2,3) was 0.555 for the whole patient cohort, 0.539 for the cardiac surgery patients, and 0.587 for the septic shock patients (all P > 0.05).

thumbnailFigure 1. Receiver operating characteristic (ROC) curves for prediction of ≥10% increase in stroke volume by pulse-pressure variation in all patients. Solid line, all fluid challenges; dotted line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity.

thumbnailFigure 2. Receiver operating characteristic (ROC) curves for prediction of ≥10% increase in stroke volume by pulse-pressure variation in cardiac surgery patients. Solid line, all fluid challenges; dotted line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity.

thumbnailFigure 3. Receiver operating characteristic (ROC) curves for prediction of ≥10% increase in stroke volume by pulse-pressure variation in septic shock patients. Solid line, all fluid challenges; dotted line, fluid challenges with concomitant increase in central venous pressure; thin solid line, line of identity.

Inclusion of only the first fluid challenge from each patient (n = 22) revealed 23% responders (n = 5). The area under the ROC curve for predicting a positive response by PPV was 0.447 in this case (P = 0.724). Inclusion of only those fluid challenges with CVP increase did not improve the prediction of increase in SV (AUC, 0.509). The threshold value for best prediction (albeit not significant) for all volume challenges was 21%.

The data were further analyzed by using a PPV threshold of ≥13%, based on other studies [22-26], and the mean threshold of 12.5% reported in a systematic review [27]. PPV was ≥13% before 46 (66%) fluid challenges: in 27 (60%) of those in cardiac surgery and in 19 (76%) in septic shock. SV increased in 13 (28%) fluid challenges: in seven (26%) in cardiac surgery and in six (32%) in septic shock. PPV was < 13% before 24 fluid challenges, and SV increased in six (25%) of them. The absolute PPV before all fluid challenges was 15 ± 13 mm Hg in cardiac surgery patients and 21 ± 18 mm Hg in sepsis patients (ns).

Right ventricular ejection fraction decreased in none of the fluid challenges resulting in increased SV, and in 44% of those in which SV did not increase (P = 0.0003). EDV increased in 28% of fluid challenges resulting in increased SV and in 45% of those in which SV did not increase (P, not significant).

Discussion

The main finding of this study was the lack of association between PPV and volume responsiveness in patients with increased pulmonary artery pressure. This was the case both in postoperative cardiac surgery patients and in patients with septic shock, despite the very different underlying circulatory pathology. Enhanced pulse-pressure variation was present before most of the clinically indicated fluid challenges. Despite this, only about one of four fluid challenges resulted in increased stroke volume. The association was no better if only those fluid challenges were considered that were preceded by pulse-pressure variation of ≥13%, a threshold proposed by several authors, and approximately the mean value (12.5%) found in a recent systematic review [27].

Our results are in sharp contrast to those of several previous studies in septic and postoperative patients, in which pulmonary artery pressure was either not increased or not reported [6,22-26,28-33], or in which pulmonary artery pressure was markedly less increased [12,34-36]. Recently, Mahjoub et al. [15] reported a failure to predict fluid responsiveness by PPV in patients who had echocardiographic findings suggesting right ventricular systolic dysfunction without overt signs of right ventricular failure. We selected patients at relevant risk of acute right ventricular dysfunction due to increased pulmonary artery pressure. Our finding of reduced right ventricular ejection fraction in almost half of the nonresponders and in none of the responders supports the concept that right ventricular dysfunction contributed to the poor predictive value of PPV. Admittedly, the reliability of right ventricular ejection fraction estimation by using thermodilution catheters is controversial. Because we did not perform concomitant echocardiography, it is conceivable, conversely, that the presence and severity of right ventricular dysfunction might have been underestimated.

Failure to induce an increase in preload and failure to detect changes in stroke volume would be the most obvious alternative explanations for this controversial finding. We consider these explanations unlikely. First, any acute increase in central venous pressure in response to volume loading suggests an increase in preload and should result in an increase in stroke volume if the heart is operating in the volume-responsive part of the cardiac-function curve [20,21,37]. The increase in central venous pressure in 76% of fluid challenges strongly suggests that preload acutely increased in the majority of fluid challenges; in those without a relevant increase in central venous pressure, the fluid challenge apparently failed to increase the stressed volume, possibly due to vasodilation. Second, the percentage of responders versus nonresponders (27% versus 73%) was the same when all fluid challenges were considered. Because no clinically applicable method provides an accurate beat-to-beat measurement of cardiac output, we chose to use the continuous thermodilution method. We used the 1-minute values provided by the software, so this method does not induce a clinically relevant delay in the measured values. Hence, relevant rapid changes should not have been missed. We also eliminated all phases of spontaneous respiration by evaluating all individual tracings, and used tidal volumes large enough (9 ml/kg on average (range, 8 to 10 ml/kg)) to result in relevant intrathoracic pressure changes [36,37].

The potential of increased pulmonary artery pressure to interfere with the predictive value of pulse-pressure variation has been addressed previously, but its clinical relevance has been considered small [13,14]. This view is in sharp contrast to the frequent occurrence of high pulmonary artery pressures in the early postoperative period after cardiac surgery [16,17], as well as in septic shock [18,19]. Because the use of the pulmonary artery catheter has decreased, moderate or transient but relevant increases in pulmonary artery pressures may easily be overlooked. Our results suggest that under these conditions, PPV may erroneously suggest volume responsiveness. The recent study of Mahjoub et al. [15] supports this concept. Those authors considered the risk of false-positive prediction of fluid responsiveness by PPV high enough to warrant echocardiography before performing fluid challenge based on increased PPV.

The dynamic association between volume status and PPV has been advocated as an alternative to predict which patients will respond to fluid administration [12,14]. We tested this in a clinical context in which fluid infusion is unavoidable (that is, in patients with septic shock and in patients immediately after cardiac surgery). Instead of selecting patients with a specific condition believed to reflect fluid responsiveness, we chose situations in which clinicians considered volume expansion with fluids necessary. Although PPV has been well validated in the context of hypovolemia [38,39], the presence of pure hypovolemia is probably less common and more difficult to treat in patients with septic shock or after cardiac surgery, when pulmonary artery pressures are increased. In these situations, complex heart-lung interactions may be present as a consequence of either compromised myocardial function in cardiac surgery patients or both diastolic and systolic biventricular dysfunction and acute changes in pulmonary vascular resistances in patients with septic shock. Previous studies in cardiac surgery patients in whom PPV predicted volume responsiveness either have been performed right after induction of anesthesia [23,24,28-30], have included patients with normal pulmonary artery pressure [24,26,30,31], or have not reported pulmonary artery pressure [22,23,28,29,32]. In studies on sepsis patients, pulmonary artery pressure was less increased than in the present study [12,34-36] (average mean pulmonary artery pressure, 24 to 26 mm Hg before fluid challenge versus 33 mm Hg in this study) or was not reported [25,33].

We believe that our findings are real, especially considering the persisting large PPV values. These increased PPV values cannot be explained by relative hypovolemia, but are rather the consequence of an impeded right systolic function, as a consequence of intrathoracic pressure changes in a situation in which the right ventricle is already at the flat part of preload dependence. Hence, PPV had no predictive value for volume responsiveness. Furthermore, clinical use of PPV to predict volume responsiveness may misleadingly suggest volume responsiveness when increased pulmonary artery pressure compromises right ventricular function, and further volume expansion may be harmful.

We therefore performed a second, experimental study. In the accompanying article [40], we assess the effect of acutely increased pulmonary artery pressure on volume-responsiveness prediction with PPV.

A limitation of this study is the lack of airway-pressure signal recording concomitant with the hemodynamic signals. Our approach does not guarantee 100% exclusion of data from patients with spontaneous respiratory activity, although respiratory efforts with an influence on PPV should mostly be detectable in central venous and pulmonary artery pressure tracings. Recording airway-pressure signals would also have enabled us to define whether PPV was the result of an increase in PP during inspiration, a decrease during expiration, or both.

Another potential confounder is the use of a colloid rather than a crystalloid. It has been suggested that colloids may have effects on cardiac function independent of their volume-expanding effect. However, this should have tended to increase fluid responsiveness rather than to decrease it.

Conclusions

We conclude that both early after cardiac surgery and in septic shock, patients with increased pulmonary artery pressure respond poorly to fluid administration. Under these conditions, PPV cannot be used to predict fluid responsiveness. We suggest that right ventricular dysfunction contributed to the poor response to fluids.

Key messages

• Septic shock and post-cardiac surgery patients with increased pulmonary artery pressure respond poorly to fluid administration.

• Pulse-pressure variation does not predict fluid responsiveness in septic shock and post-cardiac surgery patients with increased pulmonary artery pressure.

• Right ventricular dysfunction may contribute to poor fluid response in such patients.

Abbreviations

AUC: area under the curve; CVP: central venous pressure; ECG: electrocardiogram; EDV: end-diastolic volume; EF: ejection fraction; PAOP: pulmonary artery occlusion pressure; PEEP: positive end-expiratory pressure; PPV: pulse-pressure variation; ROC: receiver operating characteristic; SAPS: simplified acute physiology score; SIRS: systemic inflammatory response syndrome; SOFA: sequential organ-failure assessment; SV: stroke volume. SvO2: mixed venous oxygen saturation.

Competing interests

The Department of Intensive Care Medicine has, or has had in the past, research contracts with Abbott Nutrition International, B. Braun Medical AG, CSEM SA, Edwards Lifesciences Services GmbH, Kenta Biotech Ltd, Maquet Critical Care AB, Omnicare Clinical Research AG, and Orion Corporation; and research & development/consulting contracts with Edwards Lifesciences SA and Maquet Critical Care AB. The money is/was paid into a departmental fund; no author receives/received individual fees. The past contract with Edwards Lifesciences is unrelated to and did not influence the current study.

Authors' contributions

MWvB analyzed the data and drafted the manuscript. JT and SMJ designed and supervised the study, performed the statistics, and critically revised the manuscript. MR, FP, DT, CCG, RS, HB, and BB performed the study. All authors read and approved the final manuscript.

Acknowledgements

We are indebted to Torsten Konrad, Michael Lensch, and Natalie Araya for their skillful technical assistance and to Jeannie Wurz for careful editing of the manuscript.

References

  1. Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Valdivia A, Sailors RM, Moore FA: Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome.

    Arch Surg 2003, 138:637-642.

    discussion 642-633

    PubMed Abstract | Publisher Full Text OpenURL

  2. Mehta RL, Clark WC, Schetz M: Techniques for assessing and achieving fluid balance in acute renal failure.

    Curr Opin Crit Care 2002, 8:535-543. PubMed Abstract | Publisher Full Text OpenURL

  3. Kreimeier U, Peter K: Strategies of volume therapy in sepsis and systemic inflammatory response syndrome.

    Kidney Int Suppl 1998, 64:S75-S79. PubMed Abstract OpenURL

  4. Mythen MG, Salmon JB, Webb AR: The rational administration of colloids.

    Blood Rev 1993, 7:223-228. PubMed Abstract | Publisher Full Text OpenURL

  5. Schadt JC, Ludbrook J: Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals.

    Am J Physiol 1991, 260:H305-H318. PubMed Abstract | Publisher Full Text OpenURL

  6. Marx G, Cope T, McCrossan L, Swaraj S, Cowan C, Mostafa SM, Wenstone R, Leuwer M: Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis.

    Eur J Anaesthesiol 2004, 21:132-138. PubMed Abstract OpenURL

  7. Matejovic M, Krouzecky A, Rokyta R Jr, Novak I: Fluid challenge in patients at risk for fluid loading-induced pulmonary edema.

    Acta Anaesthesiol Scand 2004, 48:69-73. PubMed Abstract | Publisher Full Text OpenURL

  8. Roeck M, Jakob SM, Boehlen T, Brander L, Knuesel R, Takala J: Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler.

    Intensive Care Med 2003, 29:1729-1735. PubMed Abstract | Publisher Full Text OpenURL

  9. Hamilton-Davies C, Mythen MG, Salmon JB, Jacobson D, Shukla A, Webb AR: Comparison of commonly used clinical indicators of hypovolaemia with gastrointestinal tonometry.

    Intensive Care Med 1997, 23:276-281. PubMed Abstract | Publisher Full Text OpenURL

  10. Edouard AR, Degremont AC, Duranteau J, Pussard E, Berdeaux A, Samii K: Heterogeneous regional vascular responses to simulated transient hypovolemia in man.

    Intensive Care Med 1994, 20:414-420. PubMed Abstract | Publisher Full Text OpenURL

  11. Shippy CR, Appel PL, Shoemaker WC: Reliability of clinical monitoring to assess blood volume in critically ill patients.

    Crit Care Med 1984, 12:107-112. PubMed Abstract | Publisher Full Text OpenURL

  12. Michard F, Boussat S, Chemla D, Anguel N, Mercat A, Lecarpentier Y, Richard C, Pinsky MR, Teboul JL: Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure.

    Am J Respir Crit Care Med 2000, 162:134-138. PubMed Abstract | Publisher Full Text OpenURL

  13. Teboul JL, Vieillard-Baron A: Clinical value of pulse pressure variations in ARDS: still an unresolved issue?

    Intensive Care Med 2005, 31:499-500. PubMed Abstract | Publisher Full Text OpenURL

  14. Michard F, Teboul JL: Using heart-lung interactions to assess fluid responsiveness during mechanical ventilation.

    Crit Care 2000, 4:282-289. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  15. Mahjoub Y, Pila C, Friggeri A, Zogheib E, Lobjoie E, Tinturier F, Galy C, Slama M, Dupont H: Assessing fluid responsiveness in critically ill patients: false-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricle.

    Crit Care Med 2009, 37:2570-2575. PubMed Abstract | Publisher Full Text OpenURL

  16. Robitaille A, Denault AY, Couture P, Belisle S, Fortier A, Guertin MC, Carrier M, Martineau R: Importance of relative pulmonary hypertension in cardiac surgery: the mean systemic-to-pulmonary artery pressure ratio.

    J Cardiothorac Vasc Anesth 2006, 20:331-339. PubMed Abstract | Publisher Full Text OpenURL

  17. Viitanen A, Salmenpera M, Heinonen J: Right ventricular response to hypercarbia after cardiac surgery.

    Anesthesiology 1990, 73:393-400. PubMed Abstract | Publisher Full Text OpenURL

  18. Parker MM, McCarthy KE, Ognibene FP, Parrillo JE: Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans.

    Chest 1990, 97:126-131. PubMed Abstract | Publisher Full Text OpenURL

  19. Vincent JL, Reuse C, Frank N, Contempre B, Kahn RJ: Right ventricular dysfunction in septic shock: assessment by measurements of right ventricular ejection fraction using the thermodilution technique.

    Acta Anaesthesiol Scand 1989, 33:34-38. PubMed Abstract | Publisher Full Text OpenURL

  20. Guyton AC, Lindsey AW, Kaufmann BN: Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output.

    Am J Physiol 1955, 180:463-468. PubMed Abstract | Publisher Full Text OpenURL

  21. Magder S, De Varennes B: Clinical death and the measurement of stressed vascular volume.

    Crit Care Med 1998, 26:1061-1064. PubMed Abstract | Publisher Full Text OpenURL

  22. Auler JO Jr, Galas F, Hajjar L, Santos L, Carvalho T, Michard F: Online monitoring of pulse pressure variation to guide fluid therapy after cardiac surgery.

    Anesth Analg 2008, 106:1201-1206. PubMed Abstract | Publisher Full Text OpenURL

  23. Cannesson M, Desebbe O, Rosamel P, Delannoy B, Robin J, Bastien O, Lehot J-J: Pleth variability index to monitor the respiratory variations in the pulse oximeter plethysmographic waveform amplitude and predict fluid responsiveness in the operating theatre.

    Br J Anaesth 2008, 101:200-206.

    Epub 2008 Jun 2

    PubMed Abstract | Publisher Full Text OpenURL

  24. Cannesson M, Slieker J, Desebbe O, Bauer C, Chiari P, Hénaine R, Lehot J-J: The ability of a novel algorithm for automatic estimation of the respiratory variations in arterial pulse pressure to monitor fluid responsiveness in the operating room.

    Anesth Analg 2008, 106:1195-1200. PubMed Abstract | Publisher Full Text OpenURL

  25. Feissel M, Teboul JL, Merlani P, Badie J, Faller J-P, Benjelid K: Plethysmographic dynamic indices predict fluid responsiveness in septic ventilated patients.

    Intensive Care Med 2007, 33:993-999. PubMed Abstract | Publisher Full Text OpenURL

  26. Wyffels PA, Durnez PJ, Helderweirt J, Stockman WMA, De Kegel D: Ventilation-induced plethysmographic variations predict fluid responsiveness in ventilated postoperative cardiac surgery patients.

    Anesth Analg 2007, 105:448-452. PubMed Abstract | Publisher Full Text OpenURL

  27. Marik PE, Cavallazzi R, Vasu T, Hirani A: Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature.

    Crit Care Med 2009, 37:2642-2647. PubMed Abstract | Publisher Full Text OpenURL

  28. Cannesson M, Attof Y, Rosamel P, Desebbe O, Joseph P, Metton O, Bastien O, Lehot J-J: Respiratory variations in pulse oximetry plethysmographic waveform amplitude to predict fluid responsiveness in the operating room.

    Anesthesiology 2007, 106:1105-1111. PubMed Abstract | Publisher Full Text OpenURL

  29. Preisman S, Kogan S, Berkenstadt H, Perel A: Predicting fluid responsiveness in patients undergoing cardiac surgery: functional haemodynamic parameters including the Respiratory Systolic Variation Test and static preload indicators.

    Br J Anaesth 2005, 95:746-755. PubMed Abstract | Publisher Full Text OpenURL

  30. Hofer CK, Müller SM, Furrer L, Klaghofer R, Genoni M, Zollinger A: Stroke volume and pulse pressure variation for prediction of fluid responsiveness in patients undergoing off-pump coronary artery bypass grafting.

    Chest 2005, 128:848-854. PubMed Abstract | Publisher Full Text OpenURL

  31. Bendjelid K, Suter PM, Romand JA: The respiratory change in preejection period: a new method to predict fluid responsiveness.

    J Appl Physiol 2004, 96:337-342. PubMed Abstract | Publisher Full Text OpenURL

  32. Kramer A, Zygun D, Hawe H, Easton P, Ferland A: Pulse pressure variation predicts fluid responsiveness following coronary artery bypass surgery.

    Chest 2004, 126:1563-1568. PubMed Abstract | Publisher Full Text OpenURL

  33. Vieillard-Baron A, Chergui K, Rabiller A, Peyrouset O, Page B, Beauchet A, Jardin F: Superior vena caval collapsibility as a gauge of volume status in ventilated septic patients.

    Intensive Care Med 2004, 30:1734-1739. PubMed Abstract | Publisher Full Text OpenURL

  34. Michard F, Chemla D, Richard C, Wysocki M, Pinsky MR, Lecarpentier Y, Teboul JL: Clinical use of respiratory changes in arterial pulse pressure to monitor the hemodynamic effects of PEEP.

    Am J Respir Crit Care Med 1999, 159:935-939. PubMed Abstract | Publisher Full Text OpenURL

  35. Natalini G, Rosano A, Taranto M, Faggian B, Vittorielli E: Arterial versus plethysmographic dynamic indices to test responsiveness for testing fluid administration in hypotensive patients: a clinical trial.

    Anesth Analg 2006, 103:1478-1484. PubMed Abstract | Publisher Full Text OpenURL

  36. De Backer D, Heenen S, Piagnerelli M, Koch M, Vincent JL: Pulse pressure variations to predict fluid responsiveness: influence of tidal volume.

    Intensive Care Med 2005, 31:517-523. PubMed Abstract | Publisher Full Text OpenURL

  37. Magder S: Clinical usefulness of respiratory variations in arterial pressure.

    Am J Respir Crit Care Med 2004, 169:151-155. PubMed Abstract | Publisher Full Text OpenURL

  38. Berkenstadt H, Friedman Z, Preisman S, Keidan I, Livingstone D, Perel A: Pulse pressure and stroke volume variations during severe haemorrhage in ventilated dogs.

    Br J Anaesth 2005, 94:721-726. PubMed Abstract | Publisher Full Text OpenURL

  39. Fujita Y, Yamamoto T, Sano I, Yoshioka N, Hinenoya H: A comparison of changes in cardiac preload variables during graded hypovolemia and hypervolemia in mechanically ventilated dogs.

    Anesth Analg 2004, 99:1780-1786. PubMed Abstract | Publisher Full Text OpenURL

  40. Daudel Fritz, Tueller David, Krähenbühl Stefanie, Jakob StephanM, Takala Jukka: Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study.

    Crit Care 2010, in press. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL