Table 3 |
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|
Hemodynamic changes in patients with (responders) and without (nonresponders) increase in stroke volume after a volume challenge |
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|
Cardiac surgery |
Sepsis |
P value |
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|
|
|
|
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|
Before |
After |
Before |
After |
V |
V/R |
V/R/D |
|
|
|
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|
Stroke volume (ml/m2) |
0.001 |
0.699 |
|||||
|
All |
30 ± 9 |
31 ± 7 |
34 ± 6 |
36 ± 7 |
|||
|
Responders |
24 ± 4 |
29 ± 4 |
32 ± 5 |
37 ± 7 |
|||
|
Nonresponders |
32 ± 9 |
32 ± 8 |
35 ± 6 |
35 ± 7 |
|||
|
Pulmonary artery occlusion pressure (mm Hg) |
0.001 |
0.280 |
0.701 |
||||
|
All |
13 ± 3 |
14 ± 4 |
16 ± 4 |
18 ± 4 |
|||
|
Responders |
12 ± 1 |
14 ± 2 |
13 ± 4 |
18 ± 3 |
|||
|
Nonresponders |
13 ± 4 |
15 ± 4 |
16 ± 4 |
18 ± 4 |
|||
|
Central venous pressure (mm Hg) |
0.001 |
0.724 |
0.593 |
||||
|
All |
12 ± 4 |
13 ± 4 |
12 ± 5 |
14 ± 5 |
|||
|
Responders |
12 ± 3 |
13 ± 4 |
10 ± 3 |
12 ± 3 |
|||
|
Nonresponders |
12 ± 4 |
13 ± 4 |
13 ± 5 |
15 ± 5 |
|||
|
Mean pulmonary arterial pressure (mm Hg) |
0.001 |
0.158 |
0.175 |
||||
|
All |
26 ± 4 |
28 ± 5 |
33 ± 7 |
35 ± 6 |
|||
|
Responders |
27 ± 3 |
29 ± 3 |
32 ± 6 |
34 ± 7 |
|||
|
Nonresponders |
26 ± 5 |
27 ± 5 |
34 ± 7 |
35 ± 6 |
|||
|
Mean arterial pressure (mm Hg) |
0.001 |
0.206 |
0.255 |
||||
|
All |
67 ± 8 |
70 ± 9 |
58 ± 7 |
60 ± 7 |
|||
|
Responders |
69 ± 7 |
74 ± 7 |
61 ± 7 |
63 ± 9 |
|||
|
Nonresponders |
66 ± 9 |
69 ± 10 |
57 ± 7 |
59 ± 5 |
|||
|
Heart rate (beats/min) |
0.071 |
0.438 |
0.343 |
||||
|
All |
92 ± 5 |
92 ± 4 |
116 ± 22 |
114 ± 22 |
|||
|
Responders |
91 ± 4 |
91 ± 4 |
120 ± 24 |
117 ± 24 |
|||
|
Nonresponders |
92 ± 5 |
92 ± 5 |
114 ± 22 |
113 ± 22 |
|||
|
Right ventricular end-diastolic volume (ml/m2) |
0.245 |
0.385 |
0.378 |
||||
|
All |
103 ± 26 |
101 ± 25 |
122 ± 23 |
122 ± 24 |
|||
|
Responders |
103 ± 38 |
101 ± 34 |
124 ± 20 |
122 ± 21 |
|||
|
Nonresponders |
103 ± 21 |
101 ± 22 |
121 ± 25 |
122 ± 26 |
|||
|
Right ventricular ejection fraction (%) |
0.108 |
0.055 |
0.836 |
||||
|
All |
30 ± 10 |
32 ± 10 |
30 ± 6 |
29 ± 6 |
|||
|
Responders |
26 ± 9 |
28 ± 9 |
27 ± 5 |
28 ± 6 |
|||
|
Nonresponders |
32 ± 10 |
33 ± 10 |
31 ± 6 |
30 ± 6 |
|||
|
Pulse-pressure variation (%) |
0.307 |
0.573 |
0.386 |
||||
|
All |
22 ± 18 |
20 ± 17 |
34 ± 29 |
33 ± 28 |
|||
|
Responders |
22 ± 17 |
15 ± 8 |
38 ± 32 |
38 ± 38 |
|||
|
Nonresponders |
22 ± 19 |
22 ± 19 |
32 ± 29 |
30 ± 24 |
|||
|
|
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|
Values are expressed as mean ± SD. Bold indicated significant P values (P < 0.05). V, Effect of volume; V/R, volume-response interaction; V/R/D, volume-response-diagnosis interaction. |
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|
Wyler von Ballmoos et al. Critical Care 2010 14:R111 doi:10.1186/cc9060 |
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