Table 3

Outcomes

Outcome

Baxter group

(n = 14)

HES group

(n = 16)

Adjusted hazard ratio or mean difference

(95% CI, P value)^#

Mortality

Overall mortality (%)

2 (14.3)

7 (43.8)

Hazard ratio: 7.12 (0.45-112.7, P = 0.16)

Renal parameters

Continuous renal replacement therapy (%)

1 (7.1)

4 (25.0)

Hazard ratio: 6.16 (0.07-505.7, P = 0.42)

Creatinine clearance

24 hours

125.9 (20.1)

102.5 (38.8)

Mean difference: -6.5 (-26.8 to 13.7, P = 0.51)

48 hours

125.9 (25.6)

95.6 (40.3)

Mean difference: -14.7 (-37.8 to 8.4, P = 0.20

72 hours

124.2 (33.4)

97.4 (47.2)

Mean difference: -4.8 (-28.3 to 18.6, P = 0.67)

Urinary output

72 hours

165.1 (53.1)

135.8 (59.3)

Mean difference: -9.7 (-56.6 to 37.2, P = 0.67)

Pulmonary parameters

ARDS (%)

4 (28.6)

3 (18.8)

Hazard ratio: 1.26 (0.14-11.35, P = 0.84)

Ventilator days

7.4 (11.0)

12.3 (19.7)

Mean difference: -2.4 (-12.9 to 8.2, P = 0.65)

Horowitz

72 hours

237.2 (98.3)

225.4 (85.7)

Mean difference: 17.5 (-51.7 to 86.6, P = 0.61)

Surgical parameters

Beginning of surgical treatment within first 3 days (%)

10 (71.4)

9 (56.3)

Hazard ratio: 2.00 (0.58-6.93, P = 0.27)

Time to complete surgical coverage (days)

23.0 (15.7)

31.9 (30.8)

Mean difference: 1.7 (-25.2 to 28.6, P = 0.89)

Other parameters

Sepsis (%)

5 (35.7)

6 (37.5)

Hazard ratio: 0.95 (0.16-5.56, P = 0.95)

Hospital days

32.4 (16.1)

28.6 (20.7)

Mean difference: -6.7 (-22.9 to 9.6, P = 0.40)

ICU days

27.0 (14.1)

23.6 (17.4)

Mean difference: -7.6 (-21.1 to 5.8, P = 0.25)

^# Multivariable logistic regression analysis or linear regression analysis with outcome as independent and groups as dependent variable with adjustment for age, gender percent burn, acute physiology and chronic health evaluation (APACHE) II, baseline creatinine. ARDS, adult respiratory distress syndrome; CI, confidence interval; HES, hydroxyethyl starch.

Béchir et al. Critical Care 2010 14:R123   doi:10.1186/cc9086