Table 2

Time changes in pulmonary hemodynamics and ventilatory pressures

Time after injury (hours)

Control

4

8

12

18

24

MPAP, mmHg

24 ± 2

24 ± 2

28 ± 3

26 ± 2

31 ± 3

28 ± 2

PVR, mmHg

186 ± 25

134 ± 24

156 ± 22

150 ± 14

180 ± 29

145 ± 11

PCWP, mmHg

12 ± 1

15 ± 1

18 ± 1^a

14 ± 1

16 ± 1

19 ± 2^b

Ppeak, cmH₂O

20 ± 1

21 ± 2

24 ± 4

22 ± 3

30 ± 2^a

31 ± 2^a

Ppause, cmH₂O

16 ± 1

19 ± 2

22 ± 3

20 ± 3

25 ± 2^a

25 ± 3^a

Values recorded before sacrifice of animals with sham injury (control) and at different time points after induction of sepsis following acute lung injury. Each group includes four animals.

MPAP, mean pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure; Ppeak, peak airway pressure; Ppause, pause airway pressure; PVR, pulmonary vascular resistance. ^a P < 0.05, ^b P < 0.01.

Lange et al. Critical Care 2010 14:R129   doi:10.1186/cc9097