Table 2

Evolution in cerebral microcirculation over time in the septic (n = 10) and the sham (n = 5) animals

Baseline

6 hours

12 hours

18 hours^#

ANOVA

Time (P)

Groups (P)

TVD

Sepsis

6.1 ± 0.8

5.4 ± 0.5

5.7 ± 0.8

5.4 ± 0.6

0.15

0.61

Sham

5.8 ± 0.8

5.9 ± 0.7

5.6 ± 0.8

5.8 ± 0.6

0.65

TPVD

Sepsis

5.9 ± 0.9

5.1 ± 0.5

5.1 ± 0.6

4.8 ± 0.7^a

0.009

0.14

Sham

5.7 ± 0.7

5.8 ± 0.7

5.5 ± 0.7

5.5 ± 0.5

0.76

NPC

Sepsis

22.7 ± 2.8

18.8 ± 3.2 *

18.7 ± 5.9 *

17.5 ± 5.2 *^a

0.048

< 0.001

Sham

25.1 ± 0.9

24.7 ± 2.3

23.8 ± 3.3

25.8 ± 0.8

0.42

MFI

Sepsis

2.9 ± 0.1

2.9 ± 0.1

2.9 ± 0.1

2.7 ± 0.3

0.21

0.87

Sham

2.9 ± 0.1

2.9 ± 0.1

2.9 ± 0.1

2.8 ± 0.2

0.33

PSPV - HI

Sepsis

0.11 ± 0.06 *

0.26 ± 0.15 *^a

0.23 ± 0.11 *

0.32 ± 0.13 *^a

0.002

< 0.001

Sham

0.04 ± 0.01

0.03 ± 0.01

0.03 ± 0.02

0.06 ± 0.04

0.25

MFI - HI

Sepsis

0.13 ± 0.07

0.18 ± 0.13

0.23 ± 0.14 *^a

0.25 ± 0.14 *^a

0.003

0.002

Sham

0.07 ± 0.06

0.18 ± 0.09

0.08 ± 0.05

0.13 ± 0.07

0.19

Data are presented as mean ± SD.

^# Shock onset for septic group.

Significant at 5% vs. baseline (^a), vs 6 hours (^b) or vs 12 hours (^c). Significant at 5% vs. sham (*).

TVD, total vessel density; TPVD, total perfused vessel density; PSPV, proportion of small perfused vessels; FCD, functional capillary density; NPC, number of perfused capillaries; MFI, mean flow index; HI, heterogeneity index; (P) = P-value.

No interference between time and groups was found for all the studied variables in ANOVA analysis. Significant at 5% vs. baseline (^a), or vs. sham (*) in post-hoc Bonferroni correction.

Taccone et al. Critical Care 2010 14:R140   doi:10.1186/cc9205