Table 2

Pulmonary MPO, cytokine and chemokine levels in pneumococcal pneumonia after antibiotic treatment

48 hours

WT

n = 8

Heterozygous

n = 8

Homozygous

n = 7

MPO (ng/mL)

23 (20-24)

19 (17-21)

19 (14-21)

TNF-α (ng/mL)

0.8 (0.4-1.1)

0.6 (0.3-0.9)

0.6 (0.2-0.9)

IL-6 (ng/mL)

0.3 (0.2-0.4)

0.3 (0.2-0.5)

0.3 (0.2-0.6)

MCP-1 (ng/mL)

7.1 (5.5-9.4)

8.0 (5.3-10)

7.1 (5.6-10)

KC (ng/mL)

1.4 (1.1-1.7)

1.1 (0.9-1.3)

1.2 (0.9-1.4)

Data are medians (interquartile ranges). No statistical differences between the groups at either time point.

KC, keratinocyte-derived chemokine; MCP-1, monocyte chemotactic protein; MPO, myeloperoxidase; WT, wild type.

Schouten et al. Critical Care 2010 14:R145   doi:10.1186/cc9213