Evolution of IFN-γ, TNF-α and IL-10 mRNA expressions in CMNCs from DAA + (n = 16) and DAA- patients (n = 16) between inclusion (T1) and after a 36 h DAA infusion (T2). In survivors (n = 8) there is a significant lower expression of IFN-γ in the DAA+ group (*: P = 0.01, Mann-Whitney test) and also a significant decrease of IL-10 expression in survivors (DAA+ group) than in survivors of controls DAA- (**: P = 0.038, Mann-Whitney test). Box and whiskers plots show median and inter quartile range (25 to 75). Fold change is calculated as the ratio (T2-T1)/T1. DAA: drotrecogin-α activated.
Lavaux et al. Critical Care 2010 14:R163 doi:10.1186/cc9252