Table 2

Serum cytokines level of DAA+ and control groups

DAA+

N = 16

DAA-

N = 16

P

T1

T2

T1

T2

TNF-alpha (pmol/mL)

15.6(13 to 22.4)

6.6(2 to 11.4)

48(29 to 66)

35(21.1 to 85)

NS

IL-1 (pmol/mL)

32.1(17.1 to 54.1)

30.1(16 to 31)

39.6(20.8 to 58.3)

110.3(88.2 to 132.3)

NS

IL-6 (pmol/mL)

824.5(161.5 to 507.5)

140.7(38,8 to 265)

1,885(1,102.1 to 2,500)

533.2(52 to 1,992.8)

NS

IL-8 (pmol/mL)

623(102.5 to 2,348.3)

110(31.6 to 159.8)

402.3(289.1 to 754.1)

103.1(67.3 to 256.4)

NS

IL-10 (pmol/mL)

47(26.2 to 54)

12.4(8.6 to 23.3)

90(44.8 to 1048.8)

26.7(8.8 to 201.1)

NS

IFN-gamma (pmol/mL)

5(3 to 25)

2(2 to 3)

16(5.3 to 24)

2(2 to 3)

NS

Data are expressed as median (IQR 25 to 75). DAA+, septic shock patients treated with DAA. DAA-, septic shock patients contraindicated to rhAPC treatment. T1, time-point before DAA infusion; T2, time-point 36 h after infusion of DAA. The P-value, analysis of variance for repeated data (T1 and T2). NS, non-significant.

Lavaux et al. Critical Care 2010 14:R163   doi:10.1186/cc9252