Table 1

Included randomized trials

Trial

Indication

Mean age, years

Treatment

AKI criteria


Zetterström and Hedstrand [17], 1981

Elective major abdominal surgery

58.5

Postoperative crystalloid with versus without 20% albumin

At least 70% SCr and urea increase

Ginès et al. [18], 1988

Treatment of ascites in hospitalized cirrhotic patients

57.0

Paracentesis with versus without 20% albumin

At least 50% SCr or BUN increase to greater than 1.5 or 30 mg/dL, respectively

London et al. [19], 1989

CPB surgery

63.5

10% pentastarch versus 5% albumin for first 24 hours postoperatively

Emergency dialysis necessitated by acute renal failure

García-Compeán et al. [20], 1993

Hospital treatment of tense ascites causing respiratory dysfunction in cirrhotic patients

55.7

Total therapeutic paracentesis with versus without 25% albumin

Greater than 50% SCr or BUN increase to greater than 1.5 mg/dL or greater than 30 mg/dL, respectively

Dehne et al. [21], 1997

Hypovolemia in surgical ICU patients

49.1

Normocaloric parenteral nutrition with versus without 12 mL/kg per day HES 200/0.5

Acute renal failure

Gentilini et al. [22], 1999

Hospital treatment of ascites in cirrhotic patients unresponsive to bed rest and low-sodium diet

62.1

Diuretics with versus without 50 mL 25% albumin daily

Acute renal failure

Sort et al. [23], 1999

Spontaneous bacterial peritonitis

61.0

Intravenous cefotaxime with versus without 1.5 g/kg 20% albumin on day 1 plus 1.0 g/kg on day 3

Greater than 50% SCr or BUN increase and, in patients without pre-existing renal failure, greater than 1.5 mg/dL SCr or greater than 30 mg/dL BUN

Sola-Vera et al. [24], 2003

Prevention of paracentesis-induced circulatory dysfunction in cirrhotic patients with ascites

61.4

20% albumin versus saline starting 3 hours after paracentesis

Greater than 100% SCr increase to greater than 2 mg/dL

Brunkhorst et al. [25], 2008

Severe sepsis or septic shock

64.7

10% pentastarch versus Ringer's lactate

Need for renal replacement therapya

McIntyre et al. [26], 2008

Early septic shock

63.3

10% pentastarch versus normal saline

Requirement for dialysis during hospitalization

Chen et al. [27], 2009

Spontaneous bacterial peritonitis

56.5

Cephalosporins with versus without 50 mL 20% albumin on days 1 to 3

Greater than 50% SCr increase and, in patients without pre-existing renal failure, greater than 1.5 mg/dL SCr


aNeed based on the presence of acute renal failure or another indication such as volume overload or hyperkalemia. Acute renal failure, defined as a doubling of the baseline serum creatinine (SCr) level or the need for renal replacement therapy, was evaluated as an additional separate endpoint in this trial. For the meta-analysis, only the data for renal replacement therapy were used. AKI, acute kidney injury; BUN, blood urea nitrogen; CPB, cardiopulmonary bypass; HES, hydroxyethyl starch; ICU, intensive care unit.

Wiedermann et al. Critical Care 2010 14:R191   doi:10.1186/cc9308

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