Table 1

Comparison of patients with metformin-associated lactic acidosis with patients with lactic acidosis of other origin

All patients (n = 197)

MALA (n = 10)

LAOO (n = 187)

Post-cardiac arrest (n = 72)

Septic shock (n = 42)

Cardiogenic shock (n = 39)

Mesenteric ischemia (n = 8)

Hemorrhagic shock (n = 13)

Other causes (n = 13)

Age, years

67 ± 13

66 ± 9

67 ± 13

65 ± 13

68 ± 12

73 ± 11

72 ± 9

64 ± 15

56 ± 14

Male gender

121 (61%)

4 (40%)

117 (63%)

45 (62%)

24 (57%)

26 (67%)

6 (75%)

7 (54%)

9 (69%)

SAPS II

74 ± 20

88 ± 23

73 ± 19^a

81 ± 16

71 ± 19^a

75 ± 18

73 ± 25

54 ± 15^b

54 ± 14^b

SOFA score

12.5 ± 3.6

14.3 ± 1.4

12.4 ± 3.7

12.9 ± 2.9

12.1 ± 4.5

11.8 ± 2.8^b

14.4 ± 4.4

13.4 ± 4.6

9.6 ± 4.2^b

Respiratory

2.5 ± 1.0

2.7 ± 0.9

2.5 ± 1.0

2.7 ± 0.9

2.1 ± 1.3

2.4 ± 0.6

2.6 ± 1.1

2.3 ± 1.5

2.2 ± 1.4

Renal

2.4 ± 1.2

4.0 ± 0.0

2.3 ± 1.2^b

2.1 ± 1.2^b

2.5 ± 1.2^b

2.5 ± 1.1^b

2.8 ± 0.8^a

2.1 ± 1.5^b

1.9 ± 1.3^b

Hepatic

0.7 ± 1.0

0.3 ± 0.7

0.7 ± 1.0

0.3 ± 0.6

1.3 ± 1.2^a

0.6 ± 0.8

0.6 ± 0.9

1.8 ± 1.7

0.9 ± 0.9

Cardiovascular

3.3 ± 1.4

4.0 ± 0.0

3.3 ± 1.5

3.5 ± 1.3

3.2 ± 1.5

3.4 ± 1.5

4.0 ± 0.0

2.9 ± 1.8

2.1 ± 2.0^a

Hematologic

0.9 ± 1.2

0.5 ± 0.8

0.9 ± 1.2

0.6 ± 0.9

1.3 ± 1.4

0.3 ± 0.7

2.2 ± 1.6

2.6 ± 1.1

0.9 ± 1.2

Neurologic

2.7 ± 1.4

2.8 ± 1.5

2.7 ± 1.4

3.7 ± 0.6^a

1.7 ± 1.3^a

2.8 ± 1.2

2.2 ± 1.3

1.8 ± 1.4^b

1.6 ± 1.2

Lactate, mmol/L

11.6 ± 6.2

18.7 ± 5.3

11.2 ± 6.1^b

12.8 ± 6.1^b

8.7 ± 4.5^b

10.9 ± 5.2^b

8.6 ± 3.3^b

13.5 ± 9.5^b

10.8 ± 7.1^b

pH

7.13 ± 0.19

6.75 ± 0.13

7.15 ± 0.17^b

7.07 ± 0.19^b

7.23 ± 0.09^b

7.18 ± 0.14^b

7.27 ± 0.04^b

7.26 ± 0.07^b

7.14 ± 0.18^b

Bicarbonate, mmol/L

14.6 ± 5.9

4.4 ± 2.4

15.2 ± 5.6^b

14.5 ± 5.6^b

16.6 ± 5.8^b

14.9 ± 4.0^b

16.2 ± 1.8^b

15.8 ± 5.7^b

14.1 ± 8.8^b

Creatinine, μmol/L

307 ± 265

796 ± 324

227 ± 141^b

169 ± 128^b

318 ± 181^b

182 ± 48^b

299 ± 125^a

303 ± 122^a

214 ± 57^b

Survival

52 (26%)

5 (50%)

48 (26%)

19 (26%)

9 (21%)

9 (23%)

0

5 (38%)

6 (46%)

Values are presented as mean ± standard deviation or as number (percentage). Comparison with metformin-associated lactic acidosis (MALA): ^aP < 0.05, ^bP < 0.01. Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) score were measured on admission. Other causes of lactic acidosis were respiratory exhaustion (3), alcoholic lactic acidosis (3), acute liver failure (2), status epilepticus (2), anaphylactic shock, hypovolemic shock, and disseminated intravascular coagulation in acute myeloid leukemia. LAOO, lactic acidosis of other origin.

Friesecke et al. Critical Care 2010 14:R226   doi:10.1186/cc9376