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Commentary

Controversies in acute kidney injury: the 2011 Brussels Roundtable

John A Kellum1* and Claudio Ronco2

Author Affiliations

1 The Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA

2 Department Nephrology Dialysis & Transplantation San Bortolo Hospital. International Renal Research Institute (IRRIV), Vicenza, Italy

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Critical Care 2011, 15:155  doi:10.1186/cc10118

Published: 20 April 2011

Abstract

The recent advent of consensus definitions for acute kidney injury (AKI) has led to improvement in epidemiology of this complex disease and facilitated the development of new diagnostic makers and new therapies. However, important new challenges are also apparent. We still do not really understand why AKI occurs and urgently need to develop new therapies to treat it. Progress in this area will require new ideas and thinking outside the conventional box. By confronting some of the most significant controversies in the field of AKI we seek to develop new concepts that will ultimately yield new results.