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Open Access Highly Accessed Research

Transpulmonary thermodilution for hemodynamic measurements in severely burned children

Ludwik K Branski12, David N Herndon12, Jaron F Byrd12, Michael P Kinsky13, Jong O Lee12, Shawn P Fagan4 and Marc G Jeschke5*

Author Affiliations

1 Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA

2 Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA

3 Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA

4 Department of Surgery, Massachusetts General Hospital, Shriners Hospitals for Children, and Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA

5 Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, and Department of Surgery, Division of Plastic Surgery, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada

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Critical Care 2011, 15:R118  doi:10.1186/cc10147

Published: 21 April 2011

Abstract

Introduction

Monitoring of hemodynamic and volumetric parameters after severe burns is of critical importance. Pulmonary artery catheters, however, have been associated with many risks. Our aim was to show the feasibility of continuous monitoring with minimally invasive transpulmonary thermodilution (TPTD) in severely burned pediatric patients.

Methods

This prospective cohort study was conducted in patients with severe burns over 40% of the total body surface area (TBSA) who were admitted to the hospital within 96 hours after sustaining the injury. TPTD measurements were performed using the PiCCO system (Pulsion Medical Systems, Munich, Germany). Cardiac Index (CI), Intrathoracic Blood Volume Index (ITBVI) (Stewart-Hamilton equation), Extravascular Lung Water Index (EVLWI) and Systemic Vascular Resistance Index (SVRI) measurements were recorded twice daily. Statistical analysis was performed using one-way repeated measures analysis of variance with the post hoc Bonferroni test for intra- and intergroup comparisons.

Results

Seventy-nine patients with a mean age (±SD) of 9 ± 5 years and a mean TBSA burn (±SD) of 64% ± 20% were studied. CI significantly increased compared to level at admission and was highest 3 weeks postburn. ITBVI increased significantly starting at 8 days postburn. SVRI continuously decreased early in the perioperative burn period. EVLWI increased significantly starting at 9 days postburn. Young children (0 to 5 years old) had a significantly increased EVLWI and decreased ITBVI compared to older children (12 to 18 years old). EVLWI was significantly higher in patients who did not survive burn injury.

Conclusions

Continuous PiCCO measurements were performed for the first time in a large cohort of severely burned pediatric patients. The results suggest that hyperdynamic circulation begins within the first week after burn injury and continues throughout the entire intensive care unit stay.