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Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome

Karim Lakhal1, Stephan Ehrmann2, Dalila Benzekri-Lefèvre3, Isabelle Runge3, Annick Legras2, Pierre-François Dequin2, Emmanuelle Mercier2, Michel Wolff1, Bernard Régnier1 and Thierry Boulain3*

1 Service de réanimation médicale et maladies infectieuses, Hôpital Bichat-Claude Bernard, Assistance Publique des Hôpitaux de Paris, 18 rue Henri Huchard, F-75018 Paris, France

2 Service de réanimation médicale polyvalente, centre hospitalier régional universitaire de Tours, 2 boulevard Tonnelé, F-37044 Tours, France

3 Service de réanimation médicale, Hôpital La Source, centre hospitalier régional, avenue de l'Hôpital, F-45067 Orléans cedex 1, France

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Critical Care 2011, 15:R85 doi:10.1186/cc10083


See related commentary by De Backer and Scolletta, http://ccforum.com/content/15/2/150 and related letter by Mallat et al., http://ccforum.com/content/15/3/432

Published: 7 March 2011

Additional files

Additional file 1:

Additional data and figures. Impact of several clinical factors on the performance of ΔRESPPP: subgroup comparisons according to respiratory system compliance, norepinephrine dosage, neuromuscular blocking agent use and site of the artery catheter. Impact of the definition of fluid responsiveness on the performance of ΔRESPPP, individual values of baseline static and breath-derived indices in responders and nonresponders using the 15% cutoff for cardiac output to define fluid responsiveness, performance of ΔRESPPP using the 15% cutoff for cardiac output to define fluid responsiveness. Impact of chest wall compliance on ΔRESPPP provides additional comments to Figure 4. AUC, area under the receiver-operating characteristic curve; ΔRESPPP, respiratory changes in pulse pressure.

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