Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?
Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
Critical Care 2011, 15:429 doi:10.1186/cc10237
See related research by Lorente et al., http://ccforum.com/content/15/2/R97, and related letter by Chew and Thorlacius, http://ccforum.com/content/15/4/438Published: 31 May 2011
First paragraph (this article has no abstract)
Dr Lorente and colleagues  report on the interesting association between serum soluble CD40 ligand (sCD40L) levels and mortality in patients with sepsis. Some variables that can influence outcome in sepsis were accounted for in their analysis. However, the amount of transfused blood products, which may influence levels of sCD40L, was not reported.