Serum levels of ubiquitin C-terminal hydrolase-L1 protein (UCH-L1) and glial fibrillary acidic protein (GFAP) in patients with diffuse injury or focal mass lesion. (a and b) Box plots of biomarker boxes enclose 25th to 75th percentiles; vertical whiskers extend to 10th and 90th percentiles. Median (50th percentile) is marked by the line inside the box; mean is marked by the diamond; outliers are plotted with circles. (a) Serum levels of UCH-L1 versus Marshall Score (Diffuse Injury vs Focal Mass Lesion) (Kruskal-Wallis Test, P = 0.0006). (b) Serum levels GFAP versus Marshall Score (Diffuse Injury vs Focal Mass Lesion) (Kruskal-Wallis Test, P = 0.0163). (c and d) Scatterplot with average smoothing superimposed on a graph of (c) UCH-L1 and in (d) GFAP levels versus time. The figure was generated using the LOWESS (LOcally WEighted Scatterplot Smoother) technique to draw a smooth line representing the average value of the variable on the y-axis as a function of the variable on the x-axis.
Mondello et al. Critical Care 2011 15:R156 doi:10.1186/cc10286