Pathogen recognition receptor expression in rabbits submitted to mechanical ventilation or kept spontaneously breathing. Lung IL-8 mRNA levels were measured as a positive control of lung inflammation induced by mechanical ventilation (MV). mRNA levels were normalized with the expression of GAPDH mRNA. All values are shown as the fold increase compared with spontaneously breathing (SB) rabbits normalized to 1. MV induced a strong increase of toll-like receptor (TLR)2 mRNA levels, higher than TLR4, MD-2 and CD14. Results are expressed as mean ± standard deviation. *P < 0.05 between SB and MV rabbits.
Charles et al. Critical Care 2011 15:R181 doi:10.1186/cc10330