Table 4

Change in adjusted Area under the Receiver Operating Characteristic Curve

NAME

Hospital AUC_ADJ

P-value*

ICU AUC_ADJ

P-value*

(1) Established risk factors

0.820 ± 0.01

0.873 ± 0.01

(1) + LAC_ADM

0.822 ± 0.01

0.16

0.875 ± 0.01

0.24

(1) + LAC_Δ24%

0.824 ± 0.01

0.006

0.879 ± 0.01

0.009

(1) + LAC_Δ24

0.825 ± 0.01

0.005

0.879 ± 0.01

0.03

(1) + LAC_MAX24

0.827 ± 0.01

0.007

0.883 ± 0.01

0.015

(1) + LAC_TW24

0.831 ± 0.01

0.0001

0.887 ± 0.01

0.0005

(1) + LAC_MIN24

0.832 ± 0.01

< 0.0001

0.886 ± 0.01

< 0.0001

(1) + LAC_TW & LAC_Δ24

0.838 ± 0.01**

< 0.0001

0.895 ± 0.01**

< 0.0001

*compared to model (1) with established risk factors (APACHE II, diagnosis, age, gender, ventilation, surgery, date of admission and hospital)

**P < 0.01 compared to all individual measure of lactate

APACHE II, Acute Physiology and Chronic Health Evaluation II; Apache II, diagnosis, age, gender, ventilation, surgery, date of admission, mortality adjusting for established predictors of mortality; AUC_ADJ, adjusted Area under the Receiver Operating Characteristic Curve; HVHF, high-volume hemofiltration; LAC_ADM, admission lactate; LAC_TW24, time weighted lactate; LAC_MAX24, maximum lactate; LAC_MIN24, minimum lactate; LAC_Δ24, delta lactate; LAC_%Δ24, percentage change in lactate in the first 24 hours

Nichol et al. Critical Care 2011 15:R242   doi:10.1186/cc10497